IST-Mes2Homo sapiens (Human)Cancer cell line
Also known as: Istituto Scientifico Tumori-Mesothelioma 2, IstMes2, ISTMES2, IST-MES-2, IST-MES2
🤖 AI SummaryBased on 5 publications
Quick Overview
Human mesothelioma cell line for cancer research.
Detailed Summary
IST-Mes2 is a human malignant mesothelioma cell line derived from pleural effusions. It exhibits epithelioid morphology and expresses mesothelial markers such as calretinin and cytokeratins. The cell line is used in studies focusing on tumor biology, drug sensitivity, and immunotherapy strategies. However, its growth characteristics and specific genetic alterations require further investigation. Research involving IST-Mes2 contributes to understanding mesothelioma progression and therapeutic responses.
Research Applications
Cancer researchDrug sensitivity studiesImmunotherapy development
Key Characteristics
Epithelioid morphologyExpression of mesothelial markersPotential for in vivo modeling
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1312 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 71 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | ICLC |
|---|---|
| Source ID | ACH-000331_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg249Ser (c.747G>T) | Unspecified | - | PubMed=11799138, CelloPub=CLPUB00439 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
13
D16S539
11
D21S11
28,29
D5S818
12,13
D7S820
10
TH01
9
TPOX
8,11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis.
Santoni G.
BMC Cancer 6:130.1-130.7(2006).