JVM-2Homo sapiens (Human)Transformed cell line

Also known as: JVM2, JUM2 (Occasionally.)

🤖 AI SummaryBased on 15 publications

Quick Overview

Human mantle cell lymphoma cell line with known genetic features.

Detailed Summary

The JVM-2 cell line is a human mantle cell lymphoma (MCL) cell line derived from a patient with this aggressive B-cell malignancy. It is characterized by the presence of the t(11;14)(q13;q32) translocation, which leads to overexpression of cyclin D1. This cell line has been used in studies to investigate the molecular mechanisms underlying MCL, including the role of cyclin D1 in cell cycle regulation and the potential for targeted therapies. JVM-2 is also noted for its expression of specific surface markers such as CD5, CD19, and CD20, which are typical of B-cell lymphomas. Research involving JVM-2 has contributed to understanding the genetic and epigenetic alterations associated with MCL, including homozygous deletions and mutations in key tumor suppressor genes.

Research Applications

Molecular mechanisms of mantle cell lymphomaCyclin D1 overexpression and cell cycle regulationTargeted therapy developmentGenetic and epigenetic alterations in lymphomas

Key Characteristics

t(11;14)(q13;q32) translocationOverexpression of cyclin D1Expression of CD5, CD19, and CD20Homozygous deletions and mutations in tumor suppressor genes

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1319
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	63
Age Category	Adult
Sex	Female

Disease Information

Disease	Mantle cell lymphoma
Lineage	Lymphoid
Subtype	Mantle Cell Lymphoma
OncoTree Code	MCL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000106_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,13

D16S539

12,13

D18S51

13,18

D19S433

D21S11

28,30

D2S1338

17,20

D3S1358

D5S818

11,12

D7S820

10,11

D8S1179

13,15

FGA

21,23

Penta D

9,13

Penta E

TH01

6,9

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.

Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.

Cytometry A 87:285-288(2015).

DOI PubMed

Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.

O'Connor O.A.

Leuk. Lymphoma 56:2114-2122(2015).

DOI PubMed

Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.

Lenz G., Stegmeier F.

Nat. Med. 20:87-92(2014).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.

Martinez-Climent J.A.

Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).

DOI PubMed PMC

Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.

Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.

J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.

Martinez-Climent J.A.

Blood 109:271-280(2007).

DOI PubMed

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.

Colomer D., Miro R., Campo E.

Leuk. Res. 30:923-934(2006).

DOI PubMed

Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.

Williams M.E.

Leuk. Res. 30:449-457(2006).

DOI PubMed

Deletions and rearrangement of CDKN2 in lymphoid malignancy.";

Millar J.L., Catovsky D., Dyer M.J.S.

Blood 85:893-901(1995).

DOI PubMed

The establishment of cell lines from chronic B cell leukaemias: evidence of leukaemic origin by karyotypic abnormalities and Ig gene rearrangement.

Vaz de Melo J., Foroni L., Brito-Babapulle V., Luzzatto L., Catovsky D.

Clin. Exp. Immunol. 73:23-28(1988).

PubMed PMC

Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement.

Luzzatto L., Catovsky D.

Int. J. Cancer 38:531-538(1986).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org