Back to Cell Types

KO52Homo sapiens (Human)Cancer cell line

Also known as: K-052, K052

🤖 AI SummaryBased on 5 publications

Quick Overview

Human cell line with p53 mutations, used in cancer research.

Detailed Summary

The cell line KO52 is derived from human cells and is characterized by p53 gene mutations. It is utilized in research to study the role of p53 in cancer development and progression. The presence of p53 mutations in this cell line suggests its utility in understanding the mechanisms of tumorigenesis and the development of targeted therapies. Research on this cell line has contributed to the understanding of how p53 alterations affect cellular behavior and response to treatments.

Research Applications

Study of p53 gene mutations in cancerInvestigation of tumorigenesis mechanismsDevelopment of targeted cancer therapies

Key Characteristics

p53 gene mutationsHuman origin

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1321
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	46
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	HSRRB
Source ID	ACH-000498_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Trp (c.742C>T)	Homozygous	Somatic mutation acquired during proliferation	from parent cell line VCaP
MutationSimple	NRAS	p.Gly13Arg (c.37G>C)	Unspecified	-	PubMed=23455323
MutationSimple	DNMT3A	p.Arg882His (c.2645G>A)	Heterozygous	-	PubMed=30304769

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

8,12

D16S539

9,11

D5S818

11

D7S820

9,10

TH01

6,7

TPOX

8

vWA

16

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?

Uphoff C.C.

Leukemia 14:198-206(2000).

p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia.

Abo J., Inokuchi K., Dan K., Nomura T.

Blood 82:2829-2836(1993).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).