KALS-1Homo sapiens (Human)Cancer cell line

Also known as: KALS1

🤖 AI SummaryBased on 6 publications

Quick Overview

Human glioma cell line with potential for cancer research.

Detailed Summary

KALS-1 is a human glioma cell line derived from a glioblastoma multiforme (GBM) tumor. It is used in research to study the genetic and molecular mechanisms underlying glioma progression and drug resistance. The cell line has been characterized for its genomic alterations, including copy-number gains and losses, and is part of the Cancer Cell Line Encyclopedia (CCLE) and other large-scale cancer genomics projects. KALS-1 is valuable for investigating the role of specific genes and pathways in glioma biology, such as the involvement of the 5p region and the SKP2 gene in tumor development. It is also used in high-throughput screening for drug sensitivity and in understanding the impact of genetic diversity on cancer outcomes.

Research Applications

Genomic profiling of cancer cell linesDrug sensitivity screeningInvestigation of genetic alterations in gliomasStudy of tumor progression and resistance mechanisms

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used in high-throughput drug screeningCharacterized for copy-number variationsRelevant for studying glioma-specific genetic alterations

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1323
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	74
Age Category	Adult
Sex	Female

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	HSRRB
Source ID	ACH-000231_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ser241Phe (c.722C>T)	Unspecified	-	PubMed=23851445, PubMed=17260012
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	PTEN	p.Arg130Ter (c.388C>T)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

11,13

D18S51

14,19

D19S433

13,15.2

D21S11

29,32

D2S1338

18,22

D3S1358

16,18

D5S818

D7S820

10,12

D8S1179

12,13

FGA

21,23

Penta D

9,10

Penta E

12,15

TH01

TPOX

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

DOI PubMed PMC