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KE-37Homo sapiens (Human)Cancer cell line

Also known as: KE37, KE 37

🤖 AI SummaryBased on 11 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line

Detailed Summary

KE-37 is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line derived from a patient with T-cell lineage. It is commonly used in research for studying T-cell receptor (TCR) gene rearrangements and molecular mechanisms in leukemia. The cell line exhibits specific immunophenotypic markers and has been characterized for its genetic and molecular profiles, making it a valuable tool for understanding T-cell malignancies and developing targeted therapies.

Research Applications

Study of T-cell receptor (TCR) gene rearrangementsMolecular mechanisms in leukemiaImmunophenotypic characterizationGenetic and molecular profiling of T-cell malignancies

Key Characteristics

Expresses T-cell markersUsed for studying TCR gene rearrangementsCharacterized for molecular profiles

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1327
Species	Homo sapiens (Human)

Donor Information

Age	27
Age Category	Adult
Sex	Male
Subtype Features	TAL1

Disease Information

Disease	Precursor T-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	Adult T-Cell Leukemia/Lymphoma
OncoTree Code	ATLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000101_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC)	Heterozygous	-	from parent cell line HGC-27
MutationSimple	RB1	p.Gly310Glu (c.929G>A)	Heterozygous	-	from parent cell line SKW-3
MutationSimple	PTCH1	p.Arg571Gln (c.1712G>A)	Heterozygous	-	from parent cell line SKW-3
MutationSimple	NRAS	p.Gly12Asp (c.35G>A)	Unspecified	Somatic	Wistar
MutationSimple	NOTCH1	p.Gln2459Ter (c.7375C>T)	Heterozygous	-	from parent cell line SKW-3

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

8,12

D16S539

11,12

D18S51

13,18

D19S433

13,15

D21S11

28,30

D2S1338

19,25

D3S1358

15,18

D5S818

12,13

D7S820

8,12

D8S1179

11

FGA

24,25

Penta D

11,15

Penta E

5,14

TH01

6,9.3

TPOX

8

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.

Liu C., Kondo E., Minowada J., Akagi T.

Jpn. J. Cancer Res. 87:1070-1077(1996).

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).