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KNS-62Homo sapiens (Human)Cancer cell line

Also known as: KNS62

🤖 AI SummaryBased on 11 publications

Quick Overview

Human brain metastasis cell line for cancer research.

Detailed Summary

KNS-62 is a human epithelial cell line derived from a brain metastasis of bronchial squamous cell carcinoma. It exhibits epithelial characteristics and has been successfully transplanted into nude mice, where it forms tumors that mirror the histological features of the original tumor. This cell line is valuable for studying the biology of metastatic cancer and for developing therapeutic strategies. The cells maintain consistent morphological and genetic features over long-term culture, making them a reliable model for in vitro and in vivo studies.

Research Applications

Cancer metastasis studiesDrug screeningTumor biology research

Key Characteristics

Epithelial morphologyTransplantable in nude miceConsistent genetic features over long-term culture

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1335
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	49
Age Category	Adult
Sex	Male

Disease Information

Disease	Lung squamous cell carcinoma
Lineage	Lung
Subtype	Lung Squamous Cell Carcinoma
OncoTree Code	LUSC

DepMap Information

Source Type	ATCC
Source ID	ACH-000858_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg249Ser (c.747G>T)	Unspecified	-	PubMed=11799138, CelloPub=CLPUB00439
MutationSimple	RHOA	p.Leu69Pro (c.206T>C)	Heterozygous	-	Unknown, Unknown
MutationSimple	HRAS	p.Gln61Leu (c.182A>T)	Unspecified	-	from parent cell line KYSE-30
MutationSimple	DNM2	p.Pro792del (c.2370_2372delGCC)	Heterozygous	-	Unknown, Unknown
MutationSimple	CDKN2A	c.457+1G>A	Homozygous	Splice donor mutation	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

9,12

D13S317

11

D16S539

9,11

D21S11

32

D3S1358

15

D5S818

9

D7S820

11

D8S1179

13,14

FGA

23

Penta D

11,13

Penta E

10,11

TH01

7,9

TPOX

8

vWA

17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Hirohashi S., Inazawa J., Imoto I.

Hum. Mol. Genet. 14:997-1007(2005).

An epithelial cell line (KNS-62) derived from a brain metastasis of bronchial squamous cell carcinoma.

Takaki T.

J. Cancer Res. Clin. Oncol. 96:27-33(1980).

Identification and partial characterization of the unglycosylated peptide of carcinoembryonic antigen synthesized by human tumor cell lines in the presence of tunicamycin.

Kuroki M., Kuroki M., Ichiki S., Matsuoka Y.

Mol. Immunol. 21:743-746(1984).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Immunoscintigraphy of human tumors transplanted in nude mice with radiolabeled anti-ras p21 monoclonal antibodies.

Ishii N., Kohji T., Shiku H., Nagataki S.

J. Nucl. Med. 31:1520-1526(1990).