KOSC-2Homo sapiens (Human)Cancer cell line
Also known as: Kobe university Oral Squamous Cell culture-2, KOSC2CL343, KOSC-2 cl3-43, KOSC2
🤖 AI SummaryBased on 5 publications
Quick Overview
Human oral cancer cell line with PRTFDC1 silencing and potential for cancer research.
Detailed Summary
KOSC-2 is a human oral cancer cell line derived from squamous-cell carcinoma, characterized by the silencing of the PRTFDC1 gene through epigenetic mechanisms such as promoter hypermethylation. This cell line is used in research to study the role of PRTFDC1 in oral carcinogenesis and its potential as a tumor suppressor. The cell line has been utilized in studies examining the effects of DNA methylation on gene expression and the identification of genetic alterations associated with cancer progression. KOSC-2 is part of a panel of cell lines used to investigate the molecular mechanisms underlying oral cancer development and has been involved in studies related to the identification of homozygous deletions and mutations in cancer-related genes. The cell line's properties make it a valuable tool for understanding the genetic and epigenetic changes that contribute to oral cancer.
Research Applications
Study of PRTFDC1 gene silencing in oral cancerInvestigation of DNA methylation effects on gene expressionAnalysis of genetic alterations in cancer-related genesResearch on molecular mechanisms of oral cancer development
Key Characteristics
Silencing of PRTFDC1 via promoter hypermethylationUsed in studies of epigenetic changes in cancerPart of a panel for investigating oral cancer genetics
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1337 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, floor of mouth[UBERON:UBERON_0003679] |
Donor Information
| Age | 51 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001543_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln52delinsProTer (c.154_155insCAT) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | RHOA | p.Glu40Gln (c.118G>C) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | RHOA | p.Arg5Gln (c.14G>A) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
11
D16S539
9,12
D18S51
13
D21S11
29,31
D3S1358
15
D5S818
9
D7S820
10,11
D8S1179
13,16
FGA
21
Penta D
9,10
Penta E
15
TH01
6,7
TPOX
8
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Kozaki K.-i., Amagasa T., Inazawa J.
Oncogene 26:7921-7932(2007).