KP-4Homo sapiens (Human)Cancer cell line

Also known as: KP4, KP 4

🤖 AI SummaryBased on 10 publications

Quick Overview

Human pancreatic cancer cell line with PTHrP production and metabolic subtypes.

Detailed Summary

KP-4 is a human pancreatic cancer cell line established from a patient with metastatic disease. It exhibits distinct metabolic subtypes characterized by differences in glycolytic and lipogenic pathways. The cell line is known for its ability to secrete parathyroid hormone-related peptide (PTHrP), which is associated with hypercalcemia of malignancy. KP-4 and its derivatives, KP-4-1 and KP-4-2, show varying levels of PTHrP secretion and growth rates. These cell lines are valuable for studying the regulation of PTHrP production and its role in cancer progression. The cell line has been used in research to understand the molecular mechanisms of pancreatic cancer and to develop targeted therapies.

Research Applications

Metabolic profiling of cancer cellsPTHrP production and secretionDrug development for pancreatic cancerStudy of cancer cell metabolismInvestigation of tumor-specific metabolic subtypes

Key Characteristics

Secretes PTHrPMetabolic heterogeneityVaried PTHrP secretion levelsUsed in cancer research studies
Generated on 6/16/2025

Basic Information

Database IDCVCL_1338
SpeciesHomo sapiens (Human)
Tissue SourceAscites[UBERON:UBERON_0007795]

Donor Information

Age50
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseasePancreatic carcinoma
LineagePancreas
SubtypePancreatic Adenocarcinoma
OncoTree CodePAAD

DepMap Information

Source TypeRIKEN
Source IDACH-000265_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleKRASp.Gly12Asp (c.35G>A)Unspecified-PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
10
D16S539
10
D18S51
15
D21S11
29,30
D3S1358
15
D5S818
10,12
D7S820
10,11
D8S1179
11,13
FGA
21,25
Penta D
9,14
Penta E
12
TH01
9,10
TPOX
9
vWA
14
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Rottapel R., Neel B.G., Moffat J.

Cancer Discov. 2:172-189(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Establishment and characterization of PTHrP-producing human pancreatic-cancer cell-line.

Nawata H.

Int. J. Oncol. 5:33-39(1994).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).