KP-N-RT-BM-1Homo sapiens (Human)Cancer cell line

Also known as: Kyoto Pediatrics-Neuroblastoma-RT-Bone Marrow, KP-N-RT, RT-BM, KP-N-RTBM, KP-N-RT-BM, RTBM1, RT-BM 1, RT-BM-1, KPNRTBM1

🤖 AI SummaryBased on 7 publications

KP-N-RT-BM

Quick Overview

Human neuroblastoma cell line with potential for cancer research.

Detailed Summary

The KP-N-RT-BM cell line is a human neuroblastoma cell line derived from a patient with neuroblastoma. It is used in research to study the molecular mechanisms of cancer development and to test potential therapeutic strategies. This cell line has been characterized for its genetic and phenotypic features, including the presence of specific mutations and expression profiles that may contribute to its tumorigenic properties. The cell line is part of a collection of neuroblastoma cell lines that are utilized in various studies to understand the heterogeneity of neuroblastoma and to identify potential targets for treatment.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1339
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	1
Age Category	Pediatric
Sex	Female
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	HSRRB
Source ID	ACH-000345_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

9,12

D16S539

10,12

D18S51

15,17

D19S433

D21S11

30,31.2

D2S1338

D3S1358

15,17

D5S818

10,13

D7S820

10,11

D8S1179

12,13

FGA

20,21

Penta D

9,12

Penta E

12,16

TH01

6,7

TPOX

vWA

17,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.

Ohta S., Ohira M., Nakagawara A.

Cancer Lett. 331:115-121(2013).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Maris J.M.

Genes Chromosomes Cancer 43:390-403(2005).

DOI PubMed

PPM1D is a potential target for 17q gain in neuroblastoma.";

Sugimoto T., Inazawa J.

Cancer Res. 63:1876-1883(2003).

PubMed

Detection of the retinoic acid-regulated genes in a RTBM1 neuroblastoma cell line using cDNA microarray.

Ueda K.

Kurume Med. J. 48:159-164(2001).

DOI PubMed

Neuroblastoma cell lines showing smooth muscle cell phenotypes.";

Komada M., Asada Y., Sawada T.

Diagn. Mol. Pathol. 9:221-228(2000).

DOI PubMed

Identical expression of cell surface membrane antigens on two parent and eighteen cloned cell lines derived from two different neuroblastoma metastases of the same patient.

Horii Y., Morioka H., Morita M., Reynolds C.P.

Cancer Res. 46:4765-4769(1986).

PubMed

Neuroblastoma.";

Thiele C.J.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).

DOI