KP-N-SI9sHomo sapiens (Human)Cancer cell line
Also known as: SI9s, KPNSI9S, KPNSI9s, KP-N-SI9S, KP-N-S19s (Occasionally.)
🤖 AI SummaryBased on 5 publications
Quick Overview
Human neuroblastoma cell line with smooth muscle characteristics.
Detailed Summary
The KP-N-SI9s cell line is a human neuroblastoma cell line derived from the neural crest, exhibiting both neuroblastic (N-type) and substrate-adhesive (S-type) morphological features. It has been shown to express smooth muscle-specific proteins such as desmin and α-smooth muscle actin, indicating a potential for differentiation into smooth muscle cells. This cell line is used in research to study the molecular mechanisms of neuroblastoma and the differentiation potential of neural crest cells. The presence of these smooth muscle markers suggests a possible role in understanding the heterogeneity and plasticity of neuroblastoma cells.
Research Applications
Study of neuroblastoma biologyInvestigation of neural crest cell differentiationAnalysis of smooth muscle marker expression
Key Characteristics
Expression of desmin and α-smooth muscle actinMorphological diversity (N-type and S-type cells)Potential for smooth muscle differentiation
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1340 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Left axillary lymph node[UBERON:UBERON_0001097] |
Donor Information
| Age | 5 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000446_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | KRAS | p.Gly12Ala (c.35G>C) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
11,14
D16S539
9,13
D5S818
13
D7S820
8,11
TH01
6
TPOX
8,11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Neuroblastoma cell lines showing smooth muscle cell phenotypes.";
Komada M., Asada Y., Sawada T.
Diagn. Mol. Pathol. 9:221-228(2000).