KP-N-YNHomo sapiens (Human)Cancer cell line

Also known as: Kyoto Pediatrics-Neuroblastoma-YN, KPNYN

🤖 AI SummaryBased on 7 publications

Quick Overview

Human neuroblastoma cell line with MYCN amplification

Detailed Summary

The KP-N-YN cell line is a human neuroblastoma cell line derived from a long-term survivor of neuroblastoma. It is characterized by MYCN amplification, a common genetic alteration in neuroblastoma that is associated with aggressive disease and poor prognosis. This cell line has been used in studies investigating the molecular mechanisms of neuroblastoma progression and therapeutic targets. The cell line exhibits both neuroblastic (N-type) and substrate-adhesive (S-type) morphological features, reflecting the heterogeneity of neuroblastoma tumors. Research on this cell line has contributed to understanding the role of MYCN in tumor biology and the development of targeted therapies.

Research Applications

MYCN amplification studiesNeuroblastoma progression mechanismsTherapeutic target identification

Key Characteristics

MYCN amplificationN-type and S-type morphologyLong-term survivor origin

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1341
Species	Homo sapiens (Human)
Tissue Source	Right pararenal lymph node

Donor Information

Age	2
Age Category	Pediatric
Sex	Male
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	HSRRB
Source ID	ACH-000227_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

8,11

D16S539

D18S51

D19S433

D21S11

28,29

D2S1338

17,24

D3S1358

15,17

D5S818

10,11

D7S820

11,13

D8S1179

12,13

FGA

22,23

Penta D

12,13

Penta E

16,18

TH01

7,9

TPOX

8,11

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.

Ohta S., Ohira M., Nakagawara A.

Cancer Lett. 331:115-121(2013).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

PPM1D is a potential target for 17q gain in neuroblastoma.";

Sugimoto T., Inazawa J.

Cancer Res. 63:1876-1883(2003).

PubMed

Alpha-smooth-muscle actin and desmin expressions in human neuroblastoma cell lines.

Reynolds C.P., Gown A.M., Mine H., Sawada T.

Int. J. Cancer 48:277-283(1991).

DOI PubMed

Neuroblastoma.";

Thiele C.J.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).

DOI