KuramochiHomo sapiens (Human)Cancer cell line

Also known as: KURAMOCHI

🤖 AI SummaryBased on 13 publications

Quick Overview

Human high-grade serous ovarian cancer cell line with genomic and proteomic data available.

Detailed Summary

The Kuramochi cell line is a human high-grade serous ovarian cancer (HGSOC) cell line derived from a patient with ovarian cancer. It is characterized by specific genomic and proteomic features that make it a valuable model for studying HGSOC. Research has shown that Kuramochi exhibits distinct copy-number alterations and gene expression profiles that are relevant to HGSOC. It has been identified as a suitable model for in vitro studies due to its genomic similarity to HGSOC tumours. Additionally, Kuramochi has been used in studies involving drug sensitivity and therapeutic target identification, highlighting its utility in preclinical research. The cell line is also noted for its estrogen-sensitive growth characteristics when xenografted in immunocompromised mice, making it a relevant model for studying hormonal influences on ovarian cancer progression.

Research Applications

Genomic and proteomic profilingDrug sensitivity and therapeutic target identificationEstrogen-sensitive growth modelingIn vitro studies of HGSOC

Key Characteristics

Genomic similarity to HGSOC tumoursDistinct copy-number alterationsEstrogen receptor expressionSuitability for preclinical drug testing
Generated on 6/16/2025

Basic Information

Database IDCVCL_1345
SpeciesHomo sapiens (Human)
Tissue SourceAscites[UBERON:UBERON_0007795]

Donor Information

Age CategoryUnknown
SexFemale
Raceasian

Disease Information

DiseaseHigh grade ovarian serous adenocarcinoma
LineageOvary/Fallopian Tube
SubtypeHigh-Grade Serous Ovarian Cancer
OncoTree CodeHGSOC

DepMap Information

Source TypeHSRRB
Source IDACH-000524_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Asp281Tyr (c.841G>T)Unspecified-PubMed=32784519

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
9,12
D16S539
10
D18S51
13
D21S11
30,32.2
D3S1358
18
D5S818
12
D7S820
10,11
D8S1179
10,11
FGA
21,23
Penta D
10,13
Penta E
15
TH01
9
TPOX
8,12
vWA
16,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice.

Herodek B., Arteagabeitia A.B., Valenti M., Kirkin V.

Sci. Rep. 10:10799-10799(2020).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.

Velculescu V.E., Scharpf R.B.

Cell Rep. 25:2617-2633(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.

Nat. Commun. 7:12645.1-12645.14(2016).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Type-specific cell line models for type-specific ovarian cancer research.

Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.

PLoS ONE 8:E72162-E72162(2013).

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.

Takayama M., Sato A., Inazawa J.

Jpn. J. Cancer Res. 93:1114-1122(2002).

A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.

Sato A., Inazawa J.

Gynecol. Oncol. 81:172-177(2001).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Quantitative analysis on in vitro drug sensitivity of cultured human ovarian cancer cell lines.

Motoyama T.

Nihon Sanka Fujinka Gakkai Zasshi 34:308-314(1982).

Biological characterization including sensitivity to mitomycin C of cultured human ovarian cancers.

Motoyama T.

Nihon Sanka Fujinka Gakkai Zasshi 33:1197-1204(1981).

Web Resources