KYSE-150Homo sapiens (Human)Cancer cell line
Also known as: KY150, Kyse150, KYSE150, KYSE 150
Quick Overview
KYSE-150 is a human esophageal squamous cell carcinoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1348 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Esophagus[UBERON:UBERON_0001043] |
Donor Information
| Age | 49 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | asian |
Disease Information
| Disease | Squamous cell carcinoma of the esophagus |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Esophageal Squamous Cell Carcinoma |
| OncoTree Code | ESCC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000855_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Anlotinib inhibits tumor angiogenesis and promotes the anticancer effect of radiotherapy on esophageal cancer through inhibiting EphA2.
Huang J.
J. Oncol. 2022:5632744.1-5632744.11(2022).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines.
Ji J.-F., Wu K., Wu M., Zhan Q.-M.
Front. Med. China 4:412-418(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Significance of nerve growth factor overexpression and its autocrine loop in oesophageal squamous cell carcinoma.
Kaganoi J.-i., Itami A., Sakai Y., Shimada Y.
Br. J. Cancer 95:322-330(2006).
Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.
Shimada Y., Inazawa J., Imai T.
Int. J. Exp. Pathol. 86:231-240(2005).
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.
Cancer Res. 64:3741-3747(2004).
Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.
Jpn. J. Cancer Res. 91:1126-1133(2000).
Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.
Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.
Int. J. Cancer 70:437-442(1997).
Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.
Fukumoto M.
Int. J. Cancer 58:291-297(1994).