KYSE-180Homo sapiens (Human)Cancer cell line

Also known as: KY180, Kyse180, KYSE180, KYSE 180

🤖 AI SummaryBased on 7 publications

Quick Overview

KYSE-180 is a human esophageal squamous cell carcinoma cell line used in cancer research.

Detailed Summary

KYSE-180 is a human esophageal squamous cell carcinoma cell line derived from surgically resected tumors. It is widely used in research to study the molecular mechanisms of esophageal cancer, particularly focusing on genetic and epigenetic alterations. This cell line has been utilized in studies investigating the role of LRP1B in cancer progression, including its silencing through hypermethylation and homozygous deletions. Additionally, KYSE-180 has been part of comprehensive genomic and transcriptomic analyses to identify potential therapeutic targets and biomarkers for cancer treatment. The cell line is also used to explore the impact of genetic mutations and epigenetic changes on tumor behavior and drug response.

Research Applications

Study of esophageal squamous cell carcinomaInvestigation of LRP1B gene silencing mechanismsGenomic and transcriptomic profiling for therapeutic targetsAnalysis of epigenetic alterations in cancer

Key Characteristics

Used in studies on genetic and epigenetic alterations in esophageal cancerPart of comprehensive cancer genome and transcriptome analysesRelevant for understanding LRP1B inactivation mechanisms
Generated on 6/16/2025

Basic Information

Database IDCVCL_1349
SpeciesHomo sapiens (Human)
Tissue SourceEsophagus[UBERON:UBERON_0001043]

Donor Information

Age53
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseSquamous cell carcinoma of the esophagus
LineageEsophagus/Stomach
SubtypeEsophageal Squamous Cell Carcinoma
OncoTree CodeESCC

DepMap Information

Source TypeDSMZ
Source IDACH-000693_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Ile195Thr (c.584T>C)Unspecified-PubMed=12894234

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12,13
D13S317
9,12
D16S539
9
D18S51
20
D19S433
14
D21S11
30
D2S1338
27
D3S1358
15
D5S818
8,11
D7S820
9,12
D8S1179
10,12
FGA
19,21
Penta D
9
Penta E
5,12
TH01
7
TPOX
11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.

Shimada Y., Inazawa J., Imai T.

Int. J. Exp. Pathol. 86:231-240(2005).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.

Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.

Jpn. J. Cancer Res. 91:1126-1133(2000).

Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.

Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.

Int. J. Cancer 70:437-442(1997).

Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors.

Ishizaki K.

Int. J. Cancer 65:372-376(1996).

Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.

Fukumoto M.

Int. J. Cancer 58:291-297(1994).

Characterization of 21 newly established esophageal cancer cell lines.

Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.

Cancer 69:277-284(1992).