KYSE-270Homo sapiens (Human)Cancer cell line
Also known as: KY-270, Kyse270, KYSE270, KYSE 270
Quick Overview
KYSE-270 is a human esophageal squamous cell carcinoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1350 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Esophagus[UBERON:UBERON_0001043] |
Donor Information
| Age | 79 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Squamous cell carcinoma of the esophagus |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Esophageal Squamous Cell Carcinoma |
| OncoTree Code | ESCC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000873_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | c.559+1G>A (p.Val173Trpfs*59) | Homozygous | Splice donor mutation | from parent cell line U-937 |
| MutationUnexplicit | PARD3 | Ex3-25del | Homozygous | - | PubMed=20215515 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.
Shimada Y., Inazawa J., Imai T.
Int. J. Exp. Pathol. 86:231-240(2005).
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.
Cancer Res. 64:3741-3747(2004).
Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.
Jpn. J. Cancer Res. 91:1126-1133(2000).
Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.
Fukumoto M.
Int. J. Cancer 58:291-297(1994).