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KYSE-30Homo sapiens (Human)Cancer cell line

Also known as: KYSE0030, Kyse30, KYSE30, KYSE 30, Kyse-30, KYSE-300

🤖 AI SummaryBased on 11 publications

Quick Overview

KYSE-30 is a human esophageal squamous cell carcinoma cell line used in cancer research.

Detailed Summary

KYSE-30 is a human esophageal squamous cell carcinoma cell line derived from the KYSE series. It is widely used in research to study the molecular mechanisms of esophageal cancer, including genetic alterations and gene expression profiles. The cell line has been utilized in studies investigating the role of LRP1B in cancer progression and the identification of genetic mutations associated with tumor development. Additionally, KYSE-30 has been involved in research on the functional implications of p53 mutations and the impact of DNA damage on gene expression. These studies contribute to understanding the biological processes underlying esophageal cancer and may aid in the development of targeted therapies.

Research Applications

Genetic and epigenetic studies of cancerGene expression profilingInvestigation of tumor suppressor gene functionAnalysis of DNA damage responseStudy of p53 mutations and their functional implications

Key Characteristics

Used in studies of LRP1B silencing and its role in cancer progressionInvolved in research on p53 mutations and their impact on cell behaviorUtilized for understanding the molecular mechanisms of esophageal squamous cell carcinoma

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1351
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	64
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000777_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.673-2A>G (IVS6-2A>G)	Unspecified	Splice acceptor mutation	from parent cell line KYSE-30
MutationUnexplicit	PARD3	Ex3-22del	Homozygous	-	from parent cell line KYSE-30
MutationSimple	HRAS	p.Gln61Leu (c.182A>T)	Unspecified	-	from parent cell line KYSE-30
MutationSimple	CDKN2A	p.Glu120Ter (c.358G>T)	Unspecified	-	from parent cell line KYSE-30

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10

D13S317

9

D16S539

10,12

D18S51

14

D19S433

15,16

D21S11

28

D2S1338

23

D3S1358

15,16

D5S818

11

D7S820

11,11.3

D8S1179

12,15

FGA

24

Penta D

12

Penta E

13

TH01

9

TPOX

8,9

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines.

Ji J.-F., Wu K., Wu M., Zhan Q.-M.

Front. Med. China 4:412-418(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.

Fitzgerald R.C.

Dis. Esophagus 19:10-14(2006).

Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.

Shimada Y., Inazawa J., Imai T.

Int. J. Exp. Pathol. 86:231-240(2005).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

PUMA in head and neck cancer.";

Sidransky D.

Cancer Lett. 199:75-81(2003).

Gene expression profiling in human esophageal cancers using cDNA microarray.

Itami A., Yamasaki S., Imamura M.

Biochem. Biophys. Res. Commun. 286:792-801(2001).

Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.

Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.

Jpn. J. Cancer Res. 91:1126-1133(2000).

Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.

Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.

Int. J. Cancer 70:437-442(1997).

Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors.

Ishizaki K.

Int. J. Cancer 65:372-376(1996).

Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.

Fukumoto M.

Int. J. Cancer 58:291-297(1994).

Characterization of 21 newly established esophageal cancer cell lines.

Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.

Cancer 69:277-284(1992).