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KYSE-410Homo sapiens (Human)Cancer cell line

Also known as: KYSE0410, Kyse410, KYSE410, KYSE 410

🤖 AI SummaryBased on 10 publications

Quick Overview

KYSE-410 is an esophageal squamous cell carcinoma cell line used in cancer research.

Detailed Summary

KYSE-410 is a human esophageal squamous cell carcinoma cell line derived from the KYSE series. It is widely used in research to study the molecular mechanisms of esophageal cancer, including gene expression, chromosomal abnormalities, and interactions with stromal cells. This cell line has been utilized in studies examining the role of hyaluronan in cancer progression and the effects of chemotherapeutic agents on tumor cell behavior. Additionally, KYSE-410 has been employed in investigations of genetic alterations, such as homozygous deletions and mutations in genes like LRP1B and PARD3, which are associated with cancer development and progression. The cell line's characteristics make it a valuable tool for understanding the genetic and molecular basis of esophageal squamous cell carcinoma.

Research Applications

Gene expression analysisChromosomal abnormality studiesCancer progression mechanismsDrug response profilingGenetic mutation analysis

Key Characteristics

Homozygous deletions in LRP1BExpression of PARD3Interaction with fibroblastsResponse to chemotherapeutic agents

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1352
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	51
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000809_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg337Cys (c.1009C>T)	Unspecified	-	PubMed=32321971
MutationSimple	KRAS	p.Gly12Cys (c.34G>T)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

11

D16S539

10,12

D18S51

13,15

D19S433

13

D21S11

30

D2S1338

17,19

D3S1358

15,16

D5S818

13

D7S820

12

D8S1179

10

FGA

20

Penta D

11

Penta E

8,12

TH01

8

TPOX

8,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Esophageal squamous cell carcinoma cells modulate chemokine expression and hyaluronan synthesis in fibroblasts.

Grandoch M., Fischer J.W.

J. Biol. Chem. 291:4091-4106(2016).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.

Shimada Y., Inazawa J., Imai T.

Int. J. Exp. Pathol. 86:231-240(2005).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

PUMA in head and neck cancer.";

Sidransky D.

Cancer Lett. 199:75-81(2003).

Gene expression profiling in human esophageal cancers using cDNA microarray.

Itami A., Yamasaki S., Imamura M.

Biochem. Biophys. Res. Commun. 286:792-801(2001).

Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.

Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.

Jpn. J. Cancer Res. 91:1126-1133(2000).

Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.

Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.

Int. J. Cancer 70:437-442(1997).

Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.

Fukumoto M.

Int. J. Cancer 58:291-297(1994).

Characterization of 21 newly established esophageal cancer cell lines.

Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.

Cancer 69:277-284(1992).