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KYSE-520Homo sapiens (Human)Cancer cell line

Also known as: KYSE0520, Kyse520, KYSE520, KYSE 520

🤖 AI SummaryBased on 11 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line for cancer research.

Detailed Summary

KYSE-520 is a human esophageal squamous cell carcinoma cell line derived from the KYSE series. It is widely used in cancer research to study the molecular mechanisms of esophageal squamous cell carcinoma. The cell line has been characterized for its genetic and epigenetic alterations, including homozygous deletions and methylation patterns affecting tumor suppressor genes. Research on KYSE-520 has contributed to understanding the role of LRP1B in esophageal carcinogenesis and the identification of potential therapeutic targets. Additionally, it has been used in studies involving gene expression profiling and the analysis of chromosomal abnormalities.

Research Applications

Cancer researchMolecular mechanisms of esophageal squamous cell carcinomaGenetic and epigenetic alterationsTumor suppressor gene analysisGene expression profilingChromosomal abnormalities

Key Characteristics

Homozygous deletionsMethylation patternsLRP1B gene involvementGene expression profilingChromosomal instability

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1355
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	58
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000637_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.376-2A>T	Unspecified	Splice acceptor mutation	PubMed=8575860

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10

D13S317

11

D16S539

10

D18S51

14

D19S433

14,16

D21S11

29

D2S1338

19

D3S1358

16

D5S818

9

D7S820

11

D8S1179

14,16

FGA

22

Penta D

12

Penta E

15

TH01

9

TPOX

8

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.

Shimada Y., Inazawa J., Imai T.

Int. J. Exp. Pathol. 86:231-240(2005).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

PUMA in head and neck cancer.";

Sidransky D.

Cancer Lett. 199:75-81(2003).

Gene expression profiling in human esophageal cancers using cDNA microarray.

Itami A., Yamasaki S., Imamura M.

Biochem. Biophys. Res. Commun. 286:792-801(2001).

Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.

Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.

Jpn. J. Cancer Res. 91:1126-1133(2000).

Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.

Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.

Int. J. Cancer 70:437-442(1997).

Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors.

Ishizaki K.

Int. J. Cancer 65:372-376(1996).

Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.

Fukumoto M.

Int. J. Cancer 58:291-297(1994).

Characterization of 21 newly established esophageal cancer cell lines.

Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.

Cancer 69:277-284(1992).