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KYSE-70Homo sapiens (Human)Cancer cell line

Also known as: KY70, Kyse70, KYSE70, KYSE 70

🤖 AI SummaryBased on 11 publications

Quick Overview

KYSE-70 is a human esophageal squamous cell carcinoma cell line used in cancer research.

Detailed Summary

KYSE-70 is a human esophageal squamous cell carcinoma cell line derived from surgically resected tumors. It is widely used in research to study the molecular mechanisms of esophageal cancer, including genetic and epigenetic alterations. The cell line has been utilized in studies examining the role of LRP1B in cancer progression, as well as in investigations of chromosomal imbalances and gene expression profiles. KYSE-70 is also part of large-scale genomic and transcriptomic studies, contributing to the understanding of cancer biology and drug response. Its applications include the analysis of gene fusions, mutations, and the development of targeted therapies.

Research Applications

Genomic and transcriptomic studiesAnalysis of gene fusions and mutationsInvestigation of chromosomal imbalancesStudy of LRP1B in cancer progressionDevelopment of targeted therapies

Key Characteristics

Used in cancer researchPart of large-scale genomic studiesRelevant for understanding esophageal cancer biology

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1356
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	77
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000784_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ile251Thrfs*13 (c.751_752insA)	Heterozygous	-	Unknown, Unknown
MutationSimple	TP53	p.Lys120Asn (c.360G>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	ARID1A	p.Arg1989Ter (c.5965C>T)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

11,12

D16S539

13

D18S51

13

D19S433

13,16

D21S11

30

D2S1338

16

D3S1358

15

D5S818

12

D7S820

8,11

D8S1179

12

FGA

21

Penta D

9

Penta E

11

TH01

7

TPOX

8

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Hypermethylation of MAPK13 promoter in oesophageal squamous cell carcinoma is associated with loss of p38delta MAPK expression.

O'Callaghan C., Fanning L.J., Barry O.P.

Cancers (Basel) 7:2124-2133(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines.

Ji J.-F., Wu K., Wu M., Zhan Q.-M.

Front. Med. China 4:412-418(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.

Shimada Y., Inazawa J., Imai T.

Int. J. Exp. Pathol. 86:231-240(2005).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.

Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.

Jpn. J. Cancer Res. 91:1126-1133(2000).

Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.

Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.

Int. J. Cancer 70:437-442(1997).

Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors.

Ishizaki K.

Int. J. Cancer 65:372-376(1996).

Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.

Fukumoto M.

Int. J. Cancer 58:291-297(1994).

Characterization of 21 newly established esophageal cancer cell lines.

Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.

Cancer 69:277-284(1992).