L-540Homo sapiens (Human)Cancer cell line
Also known as: L540, L 540
Quick Overview
L-540 is a Hodgkin lymphoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1362 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 20 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Hodgkin lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Hodgkin Lymphoma |
| OncoTree Code | HL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000806_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Biol. Chem. 399:511-523(2018).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A mass spectrometric-derived cell surface protein atlas.";
Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
PLoS ONE 10:E0121314-E0121314(2015).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Kutok J.L., Shipp M.A.
Blood 116:3268-3277(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Sturzenhofecker B., Kube D.
Leuk. Lymphoma 47:1932-1940(2006).
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Lagercrantz S., Enblad G.
Cancer Genet. Cytogenet. 141:43-48(2003).
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Gaulton G.N., Ratajczak M.Z.
Leukemia 14:1821-1832(2000).
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Quentmeier H., Drexler H.G.
Leukemia 10:142-149(1996).
Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4).
Hansen H., Sterry W., Parwaresch M.R., Lemke H.
Int. J. Cancer 60:539-544(1995).
Hodgkin's disease: establishment and characterization of four in vitro cell lines.
Boie C.
J. Cancer Res. Clin. Oncol. 101:111-124(1981).
Hodgkin's disease cell lines: characteristics and biological activities.
Stein H., Gerdes J., Heit W.F.W., Ziegler A.
Haematol. Blood Transfus. 28:411-417(1983).
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Ziegler A., Heit W.F.W., Diehl V.
Dtsch. Med. Wochenschr. 108:936-944(1983).
Biology of Hodgkin cell lines.";
Tesch H., Fonatsch C., Stein H., Diehl V.
Recent Results Cancer Res. 117:53-61(1989).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).