LC-1FHomo sapiens (Human)Cancer cell line
Also known as: Lung cancer-1/squamous, floating variant, LC1F
🤖 AI SummaryBased on 3 publications
Quick Overview
LC-1F is a squamous cell lung cancer cell line used for research on cancer subtypes and drug sensitivity.
Detailed Summary
LC-1F is a squamous cell lung cancer cell line that has been characterized in research studies for its molecular subtypes and drug sensitivity. It is part of a larger dataset of 28 squamous cell lung cancer cell lines used to analyze gene expression profiles and their correlation with drug responses. The cell line is classified as a classical subtype based on its gene expression patterns, which may influence its sensitivity to certain anticancer drugs. Research has shown that LC-1F exhibits specific responses to drugs such as Panobinostat, 17-AAG, Irinotecan, Topotecan, and Paclitaxel, but it is less sensitive compared to other subtypes like the basal or primitive types. The cell line's classification and drug response data are valuable for understanding the heterogeneity of squamous cell lung cancer and for developing targeted therapies.
Research Applications
Analysis of squamous cell lung cancer subtypesDrug sensitivity profilingGene expression profiling
Key Characteristics
Classical subtype classificationSensitivity to specific anticancer drugsPart of a larger dataset of 28 squamous cell lung cancer cell lines
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1372 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 69 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Lung squamous cell carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Squamous Cell Carcinoma |
| OncoTree Code | LUSC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000705_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Met237Ile (c.711G>T) | Unspecified | - | from parent cell line T98G |
| MutationSimple | SPEN | p.Arg1475Ter (c.4423C>T) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
12
D16S539
9
D5S818
12,13
D7S820
12
TH01
7,9
TPOX
8,12
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).