LCLC-103HHomo sapiens (Human)Cancer cell line

Also known as: Large Cell Lung Cancer-103H, LCLC103H

🤖 AI SummaryBased on 6 publications

Quick Overview

Human non-small-cell lung cancer cell line with potential for drug sensitivity studies.

Detailed Summary

LCLC-103H is a human non-small-cell lung cancer cell line derived from a pleural effusion. It is characterized by large cell morphology and the presence of giant cells. This cell line has been used in studies related to cancer cell line diversity and genetic ancestry, highlighting its utility in understanding tumor heterogeneity and disparities in cancer research. LCLC-103H has been part of efforts to catalog genetic variations and neo-epitopes for immunotherapy research. Its properties make it a valuable model for investigating the molecular mechanisms of lung cancer and for developing targeted therapies.

Research Applications

Cancer researchDrug sensitivity studiesImmunotherapy researchGenetic variation analysis

Key Characteristics

Non-small-cell lung cancerLarge cell morphologyGiant cellsPleural effusion origin

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1375
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	61
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung large cell carcinoma
Lineage	Lung
Subtype	Large Cell Lung Carcinoma
OncoTree Code	LCLC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000627_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val216Leu (c.646G>T)	Homozygous	-	Unknown, Unknown
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

D18S51

D19S433

D21S11

29,31.2

D2S1338

16,19

D3S1358

16,17

D5S818

11,12

D7S820

8,11

D8S1179

12,14

FGA

Penta D

Penta E

TH01

TPOX

vWA

14,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines.

Jaques G., Gropp C., Haeder M.

Differentiation 37:158-171(1988).

DOI PubMed

Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.

Carney D.N., Vooijs G.P., Ramaekers F.C.S.

J. Cell Sci. 91:91-108(1988).

DOI PubMed

Novel antigens characteristic of neuroendocrine malignancies.";

Boerman O.C., Ramaekers F.C.S.

Cancer 67:619-633(1991).

DOI PubMed