LCLC-97TM1Homo sapiens (Human)Cancer cell line

Also known as: Large Cell Lung Cancer-97TM1, LCLC97TM1, LCL97TM

🤖 AI SummaryBased on 7 publications

Quick Overview

Human non-small cell lung cancer cell line with large cell morphology.

Detailed Summary

LCLC-97TM1 is a human non-small cell lung cancer cell line derived from a primary tumor. It exhibits large cell morphology with features of undifferentiated carcinoma. The cell line shows high proliferation rates with a population doubling time of 26 hours. It has been used in studies related to cancer biology, drug response, and molecular profiling. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized for its genomic and transcriptomic features. Research on this cell line has contributed to understanding of cancer progression and therapeutic targets.

Research Applications

Cancer biologyDrug responseMolecular profiling

Key Characteristics

Large cell morphologyUndifferentiated carcinomaHigh proliferation rate

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1376
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	44
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung large cell carcinoma
Lineage	Lung
Subtype	Large Cell Lung Carcinoma
OncoTree Code	LCLC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000596_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Leu35Cysfs*9 (c.102delC)	Heterozygous	-	Unknown, Unknown
MutationSimple	KRAS	p.Gly12Val (c.35G>T)	Heterozygous	Acquired	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

11,13

D16S539

12,13

D18S51

D19S433

D21S11

27,30

D2S1338

D3S1358

D5S818

10,12

D7S820

10,10.2,11

D8S1179

FGA

Penta D

12,15

Penta E

TH01

TPOX

8,11

vWA

19,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Comparative proteome analysis across non-small cell lung cancer cell lines.

Daub H.

J. Proteomics 130:1-10(2016).

DOI PubMed

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines.

Jaques G., Gropp C., Haeder M.

Differentiation 37:158-171(1988).

DOI PubMed