LK-2Homo sapiens (Human)Cancer cell line
Also known as: LK2, LK 2
Quick Overview
LK-2 is a human lung cancer cell line used in cancer research.
Detailed Summary
Basic Information
Database ID | CVCL_1377 |
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Species | Homo sapiens (Human) |
Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
Age | 74 |
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Age Category | Adult |
Sex | Male |
Disease Information
Disease | Lung squamous cell carcinoma |
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Lineage | Lung |
Subtype | Lung Squamous Cell Carcinoma |
OncoTree Code | LUSC |
DepMap Information
Source Type | RIKEN |
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Source ID | ACH-000769_source |
Known Sequence Variations
Type | Gene/Protein | Description | Zygosity | Note | Source |
---|---|---|---|---|---|
MutationSimple | TP53 | p.Val272Met (c.814G>A) | Unspecified | - | from parent cell line TE-1 |
MutationSimple | CDKN2A | p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T) | Homozygous | - | from parent cell line DU145 |
MutationSimple | APC | p.Trp685Ter (c.2055G>A) | Homozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Hum. Cell 37:944-950(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Br. J. Cancer 109:1599-1608(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Igishi T., Burioka N., Nanba E., Shimizu E.
Cancer Biol. Ther. 13:369-378(2012).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Cancer Res. 65:7276-7282(2005).
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hirohashi S., Inazawa J., Imoto I.
Hum. Mol. Genet. 14:997-1007(2005).
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.
Clin. Cancer Res. 9:4705-4713(2003).
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Kohara H., Harada M.
Acta Med. Okayama 53:67-75(1999).