LoucyHomo sapiens (Human)Cancer cell line

Also known as: LOUCY

🤖 AI SummaryBased on 6 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line with unique chromosomal translocation.

Detailed Summary

The Loucy cell line is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line established from the peripheral blood of a patient. It exhibits a distinct immunophenotype, characterized by expression of OKT3 and OKT4 markers, and lacks expression of OKT6, OKT8, and TdT. Cytogenetic analysis revealed a unique translocation between chromosomes 16 and 20 (t(16;20)(p12;q13)), along with a deletion of 5q and loss of an entire X chromosome. This cell line provides a valuable model for studying the genetic and molecular mechanisms underlying T-ALL, particularly the role of chromosomal translocations in leukemogenesis. The presence of this specific translocation may offer insights into the pathogenesis of T-ALL and could be useful for developing targeted therapies.

Research Applications

Study of chromosomal translocations in T-ALLInvestigation of leukemogenesis mechanismsDevelopment of targeted therapies

Key Characteristics

Unique t(16;20)(p12;q13) translocation5q deletionX chromosome lossDistinct immunophenotype (OKT3+, OKT4+, TdT-)

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1380
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	38
Age Category	Adult
Sex	Female
Race	caucasian
Subtype Features	ETP-like

Disease Information

Disease	Precursor T-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	Early T-Cell Precursor Lymphoblastic Leukemia
OncoTree Code	ETPLL

DepMap Information

Source Type	ATCC
Source ID	ACH-000104_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val272Met (c.814G>A)	Unspecified	-	from parent cell line TE-1
Gene fusion	NUP214	SET-NUP214	-	-	PubMed=19166587

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D10S1248

D12S391

D13S317

11,13

D16S539

D18S51

15,16

D19S433

D1S1656

14,15

D21S11

27,30

D22S1045

15,16

D2S1338

21,22

D2S441

10,12

D3S1358

15,19

D5S818

11,12

D7S820

9,10

D8S1179

12,13

FGA

Penta D

10,13

Penta E

7,13

TH01

8,9.3

TPOX

8,9

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines.

MacLeod R.A.F., Drexler H.G.

J. Hematol. Oncol. 2:3.1-3.5(2009).

DOI PubMed PMC

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOI PubMed

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOI PubMed

Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation.

Ben-Bassat H., Shlomai Z., Kohn G., Prokocimer M.

Cancer Genet. Cytogenet. 49:241-248(1990).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

humantallcelllines.wordpress.com genome.ucsc.edu