LS123Homo sapiens (Human)Cancer cell line

Also known as: Laboratory of Surgery 123, LS-123, LS 123, Ls123, LS153

🤖 AI SummaryBased on 14 publications

Quick Overview

Human colon adenocarcinoma cell line with low invasive potential.

Detailed Summary

LS123 is a human colon adenocarcinoma cell line established from a primary colon tumor. It exhibits low invasive potential and does not form tumors in nude mice. The cell line is aneuploid and releases low levels of CEA. LS123 cells grow in enriched semisolid medium and form colonies in specific conditions. They show limited mitotic activity and do not display aggressive tumor formation in vivo. The cell line is useful for studying the characteristics of colon cancer with minimal invasiveness.

Research Applications

Cancer biology studiesDrug sensitivity testingTumor marker analysis

Key Characteristics

AneuploidLow CEA productionNon-tumorigenic in nude miceLimited invasive potential
Generated on 6/16/2025

Basic Information

Database IDCVCL_1383
SpeciesHomo sapiens (Human)
Tissue SourceColon[UBERON:UBERON_0001155]

Donor Information

Age65
Age CategoryAdult
SexFemale
Racecaucasian

Disease Information

DiseaseColon adenocarcinoma
LineageBowel
SubtypeColon Adenocarcinoma
OncoTree CodeCOAD

DepMap Information

Source TypeATCC
Source IDACH-000501_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg175His (c.524G>A)UnspecifiedSomatic mutation acquired during proliferationfrom parent cell line YCC-3
MutationSimpleKRASp.Gly12Ser (c.34G>A)Unspecified-PubMed=27004849
MutationSimpleAPCp.Arg1450Ter (c.4348C>T)Unspecified-PubMed=24755471
MutationSimpleAPCp.Gln625Ter (c.1873C>T)Heterozygous-Unknown, Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,11
D13S317
9,13
D16S539
13
D18S51
16
D19S433
14
D21S11
30
D2S1338
19
D3S1358
16,18
D5S818
11
D7S820
9
D8S1179
13,16
FGA
22
Penta D
9,11
Penta E
5,12
TH01
7,8
TPOX
9
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Pharmacoproteomic characterisation of human colon and rectal cancer.

Weichert W., Knapp S., Feller S.M., Kuster B.

Mol. Syst. Biol. 13:951-951(2017).

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.

Br. J. Cancer 103:340-346(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.

Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.

Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).

Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.

Liu Y., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).

Characterization of a human colonic adenocarcinoma cell line, LS123.

Kahan B.D.

In Vitro 19:99-107(1983).

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