Lu-134-AHomo sapiens (Human)Cancer cell line

Also known as: Lu134AH, Lu134-AH, Lu134-A-H, LU-134-AH, Lu-134-AH, LU-134-A-H, Lu-134-A-H, NCC-c-Lu-134-A-H, Lu134, Lu-134, LU-134, Lu134A, Lu-134A, LU-134A, LU-134-A, Lu-134-a

🤖 AI SummaryBased on 13 publications

Quick Overview

Human lung cancer cell line with known mutations in DCC and p53 genes.

Detailed Summary

Lu-134-A is a human lung cancer cell line derived from small-cell lung carcinoma. It has been extensively studied for genetic alterations, including mutations in the DCC and p53 genes. Research indicates that this cell line exhibits specific genetic profiles associated with lung cancer progression. The DCC gene shows mutations, and p53 mutations are prevalent, contributing to tumorigenesis. These characteristics make Lu-134-A a valuable model for studying lung cancer mechanisms and therapeutic targets.

Research Applications

Genetic mutation analysisCancer progression studiesTherapeutic target identification

Key Characteristics

DCC gene mutationsp53 mutationsSmall-cell lung carcinoma origin
Generated on 6/16/2025

Basic Information

Database IDCVCL_1387
SpeciesHomo sapiens (Human)
Tissue SourceLung[UBERON:UBERON_0002048]

Donor Information

Age80
Age CategoryAdult
SexMale

Disease Information

DiseaseSmall cell lung cancer
LineageLung
SubtypeSmall Cell Lung Cancer
OncoTree CodeSCLC

DepMap Information

Source TypeRIKEN
Source IDACH-002051_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Pro278Leu (c.833C>T)Homozygous-PubMed=27270441

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12
D13S317
9
D16S539
9
D5S818
11
D7S820
11
TH01
9
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.

Kasai F., Fukushima M., Miyagi Y., Nakamura Y.

Hum. Cell 37:944-950(2024).

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.

Yokota J.

Genes Chromosomes Cancer 52:802-816(2013).

Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.

Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.

Cancer Sci. 101:1891-1896(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

A gene-alteration profile of human lung cancer cell lines.";

Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.

Hum. Mutat. 30:1199-1206(2009).

Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.

Nakagawa K., Nomura H., Ishikawa Y.

Lancet 363:775-781(2004).

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

Inazawa J.

Am. J. Pathol. 161:207-216(2002).

Mutation and expression of the DCC gene in human lung cancer.";

Yokota J.

Neoplasia 2:300-305(2000).

Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.

Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.

Int. J. Oncol. 15:927-934(1999).

Establishment of a drug sensitivity panel using human lung cancer cell lines.

Kohara H., Harada M.

Acta Med. Okayama 53:67-75(1999).

Small cell lung cancer can express CD34 antigen.";

Hiraki A., Ueoka H., Harada M.

Anticancer Res. 17:3627-3632(1997).

Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.

Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.

Anticancer Drug Des. 8:417-428(1993).

Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.

Kashii T., Mizushima Y., Monno S., Nakagawa K., Kobayashi M.

J. Cancer Res. Clin. Oncol. 120:143-148(1994).

Interconversion of biological characteristics of small cell lung cancer depending on culture conditions.

Kato K., Ichinose H., Nagatsu T., Hasegawa T.

Gann 75:1089-1099(1984).

Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.

Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.

Jpn. J. Clin. Oncol. 16:203-212(1986).

Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.

Saijo N.

Cancer Chemother. Pharmacol. 27:263-270(1991).

Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.

Sugimura T., Terada M., Yokota J.

Oncogene 7:451-457(1992).

Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.

Higuchi H., Uei Y.

Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985).