Lu-134-AHomo sapiens (Human)Cancer cell line
Also known as: Lu134AH, Lu134-AH, Lu134-A-H, LU-134-AH, Lu-134-AH, LU-134-A-H, Lu-134-A-H, NCC-c-Lu-134-A-H, Lu134, Lu-134, LU-134, Lu134A, Lu-134A, LU-134A, LU-134-A, Lu-134-a
Quick Overview
Human lung cancer cell line with known mutations in DCC and p53 genes.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
Database ID | CVCL_1387 |
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Species | Homo sapiens (Human) |
Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
Age | 80 |
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Age Category | Adult |
Sex | Male |
Disease Information
Disease | Small cell lung cancer |
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Lineage | Lung |
Subtype | Small Cell Lung Cancer |
OncoTree Code | SCLC |
DepMap Information
Source Type | RIKEN |
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Source ID | ACH-002051_source |
Known Sequence Variations
Type | Gene/Protein | Description | Zygosity | Note | Source |
---|---|---|---|---|---|
MutationSimple | TP53 | p.Pro278Leu (c.833C>T) | Homozygous | - | PubMed=27270441 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Hum. Cell 37:944-950(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Yokota J.
Genes Chromosomes Cancer 52:802-816(2013).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Nakagawa K., Nomura H., Ishikawa Y.
Lancet 363:775-781(2004).
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Inazawa J.
Am. J. Pathol. 161:207-216(2002).
Mutation and expression of the DCC gene in human lung cancer.";
Yokota J.
Neoplasia 2:300-305(2000).
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.
Int. J. Oncol. 15:927-934(1999).
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Kohara H., Harada M.
Acta Med. Okayama 53:67-75(1999).
Small cell lung cancer can express CD34 antigen.";
Hiraki A., Ueoka H., Harada M.
Anticancer Res. 17:3627-3632(1997).
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.
Anticancer Drug Des. 8:417-428(1993).
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Kashii T., Mizushima Y., Monno S., Nakagawa K., Kobayashi M.
J. Cancer Res. Clin. Oncol. 120:143-148(1994).
Interconversion of biological characteristics of small cell lung cancer depending on culture conditions.
Kato K., Ichinose H., Nagatsu T., Hasegawa T.
Gann 75:1089-1099(1984).
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.
Jpn. J. Clin. Oncol. 16:203-212(1986).
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Saijo N.
Cancer Chemother. Pharmacol. 27:263-270(1991).
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Sugimura T., Terada M., Yokota J.
Oncogene 7:451-457(1992).
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Higuchi H., Uei Y.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985).