Lu-165Homo sapiens (Human)Cancer cell line
Also known as: LU165, LU-165
🤖 AI SummaryBased on 4 publications
Quick Overview
Human small cell lung cancer cell line producing ADH.
Detailed Summary
Lu-165 is a human small cell lung cancer (SCLC) cell line established from a 50-year-old Indonesian male patient with syndrome of inappropriate antidiuretic hormone secretion (SIADH). This cell line is notable for its high production of anti-diuretic hormone (ADH), with levels reaching 2.8 mg/g protein. Lu-165 cells exhibit a suspended growth pattern and show immunoreactivity for ADH in the cytoplasm. The cell line has been used in studies to investigate the biochemical and morphological characteristics of ADH-producing SCLC, as well as the mechanisms of ADH production and regulation. It has also been utilized in transplantation studies to evaluate tumor growth in nude mice. The cell line is part of a collection of SCLC cell lines that have been characterized for their genetic and molecular profiles, contributing to the understanding of SCLC biology and potential therapeutic targets.
Research Applications
ADH production and regulationSCLC biologyTumor transplantation in nude miceGenetic and molecular profiling
Key Characteristics
High ADH productionSuspended growth patternCytoplasmic ADH immunoreactivityEstablished from SIADH patient
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1391 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 50 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002077_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Val157Profs*9 (c.468_480delCGTCCGCGCCATG) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | PTEN | p.Gly36Arg (c.106G>A) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
10
D16S539
9,11
D5S818
9,13
D7S820
12
TH01
9
TPOX
8,9
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Hum. Cell 37:944-950(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Inazawa J.
Am. J. Pathol. 161:207-216(2002).