MES-SAHomo sapiens (Human)Cancer cell line

Also known as: MESSA

🤖 AI SummaryBased on 5 publications

Quick Overview

Human sarcoma cell line for cancer research and drug screening.

Detailed Summary

MES-SA is a human sarcoma cell line derived from a malignant tumor, widely used in cancer research for studying sarcoma biology and drug responses. It is part of a panel of 63 sarcoma cell lines screened for drug sensitivity, showing varied responses to targeted therapies. The cell line is utilized in studies involving molecular profiling, gene expression, and microRNA analysis to identify potential therapeutic targets. Its use in research highlights the importance of understanding genetic and molecular mechanisms in sarcoma progression and treatment.

Research Applications

Cancer researchDrug screeningMolecular profilingGene expression analysisMicroRNA analysis

Key Characteristics

Used in sarcoma drug sensitivity screeningPart of a large panel of sarcoma cell linesUtilized for molecular and genetic studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1404
Species	Homo sapiens (Human)
Tissue Source	Uterus[UBERON:UBERON_0000995]

Donor Information

Age	56
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Sarcoma of the corpus uteri
Lineage	Uterus
Subtype	Uterine Sarcoma/Mesenchymal
OncoTree Code	USARC

DepMap Information

Source Type	ATCC
Source ID	ACH-000449_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	PTEN	p.His272Thrfs*4 (c.813delT) (p.Phe271fs) (c.811delT)	Heterozygous	-	from parent cell line MES-SA
MutationSimple	ARID1A	p.Thr1690Asnfs*8 (c.5068dupA) (c.5067_5068insA)	Heterozygous	-	from parent cell line MES-SA
MutationSimple	ARID1A	p.Gly1610Trpfs*38 (c.4826dupC) (p.S1609fs) (c.4825_4826insC)	Heterozygous	-	from parent cell line MES-SA
Gene deletion	CDKN2A	-	Homozygous	Possible	PubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

14,15

D12S391

17,25

D13S317

11,13

D16S539

11,12

D18S51

12,15

D19S433

14.2,15

D1S1656

14,17.3

D21S11

29,30.2

D22S1045

D2S1338

D2S441

10,14

D3S1358

14,17

D5S818

D7S820

7,11

D8S1179

14,15

FGA

20,25

Penta D

13,15

Penta E

7,10

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.

Harris E., Monks A., Morris J.

Mol. Cancer Ther. 14:2452-2462(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Proteomic analysis of proteins responsible for the development of doxorubicin resistance in human uterine cancer cells.

Chang M.D.-T., Chan H.-L.

J. Proteomics 75:5822-5847(2012).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Human sarcoma cell lines MES-SA and MES-SA/Dx5 as a model for multidrug resistance modulators screening.

Michalak K.

Anticancer Res. 25:383-389(2005).

PubMed

Development and characterization of a human sarcoma cell line, MES-SA, sensitive to multiple drugs.

Harker W.G., MacKintosh F.R., Sikic B.I.

Cancer Res. 43:4943-4950(1983).

PubMed

Web Resources

thermofisher.com tcpaportal.org