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MFE-280Homo sapiens (Human)Cancer cell line

Also known as: MFE280, MFE 280

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line with potential for drug sensitivity studies.

Detailed Summary

MFE-280 is a human cancer cell line derived from an unspecified tissue and disease type. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to drug sensitivity and predictive modeling. The cell line has been profiled for genomic and pharmacological data, contributing to the understanding of cancer biology and therapeutic strategies. Research involving MFE-280 has focused on identifying genetic predictors of drug response and exploring the relationship between mutations and cancer progression. The cell line's utility in drug development and cancer research is highlighted by its inclusion in large-scale studies and its availability for in vitro experimentation.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1405
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	77
Age Category	Adult
Sex	Female

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000192_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.919+1G>C (IVS8+1G>C)	Heterozygous	Splice donor mutation	PubMed=29970484
MutationSimple	PIK3CA	p.His1047Tyr (c.3139C>T)	Heterozygous	-	Unknown, Unknown, PubMed=28273451, PubMed=25230021, PubMed=24224046, PubMed=22705003

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

9,12

D13S317

10,12

D16S539

12

D18S51

13,18

D19S433

13,16

D21S11

30

D2S1338

19,20

D3S1358

18

D5S818

11,12

D7S820

10

D8S1179

13

FGA

21,24

Penta D

9

Penta E

7,13

TH01

7

TPOX

9,10

vWA

17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Establishment of new epithelial carcinoma cell lines by blocking monolayer formation.

Hackenberg R., Hawighorst T., Hild F., Schulz K.-D.

J. Cancer Res. Clin. Oncol. 123:669-673(1997).

Expression of placental protein 14 by the new endometrial cancer cell line MFE-280 in vitro and by endometrial carcinomas in vivo.

Hackenberg R., Loos S., Nia A.H., Kunzmann R., Schulz K.-D.

Anticancer Res. 18:1153-1158(1998).

Web Resources