MHH-CALL-2Homo sapiens (Human)Cancer cell line

Also known as: MHHCALL2, MHH-CALL2, Mhh-Call 2

🤖 AI SummaryBased on 7 publications

Quick Overview

MHH-CALL-2 is a human cell line derived from acute myeloid leukemia, characterized by the JAK2 V617F mutation and specific chro...

Detailed Summary

MHH-CALL-2 is a human cell line established from a patient with acute myeloid leukemia (AML). It is notable for harboring the JAK2 V617F mutation, a key driver in myeloproliferative disorders. This cell line exhibits specific chromosomal abnormalities, including losses of heterozygosity (LOH) on chromosome 9p, which are associated with the pathogenesis of myeloid malignancies. The presence of the JAK2 V617F mutation and LOH on 9p makes MHH-CALL-2 a valuable model for studying the molecular mechanisms underlying myeloproliferative disorders and AML. It is also used in research to investigate the role of JAK2 signaling in leukemogenesis and to test therapeutic strategies targeting JAK2 mutations.

Research Applications

Study of JAK2 V617F mutation in myeloproliferative disordersInvestigation of chromosomal abnormalities in AMLAnalysis of LOH on chromosome 9p in myeloid malignanciesDevelopment of targeted therapies for JAK2-mutated leukemias

Key Characteristics

JAK2 V617F mutationLoss of heterozygosity on chromosome 9pRelevance to myeloproliferative disorders and AML

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1409
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	15
Age Category	Pediatric
Sex	Female
Race	caucasian
Subtype Features	Near haploid

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma with Hypodiploidy
OncoTree Code	BLLHYPO

DepMap Information

Source Type	DSMZ
Source ID	ACH-000020_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

12,14

D19S433

D21S11

29,30

D2S1338

D3S1358

D5S818

D7S820

D8S1179

FGA

Penta D

9,12

Penta E

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

Janssen J.W.G., Drexler H.G.

Leukemia 11:441-447(1997).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI