MHH-CALL-4Homo sapiens (Human)Cancer cell line

Also known as: MHHCALL4, MHH-CALL4

🤖 AI SummaryBased on 6 publications

Quick Overview

MHH-CALL-4 is a human cell line derived from B-cell precursor acute lymphoblastic leukemia (B-ALL) with the t(1;19)(q23;p13) tr...

Detailed Summary

MHH-CALL-4 is a human B-cell precursor acute lymphoblastic leukemia (B-ALL) cell line established from a patient with B-ALL. It carries the t(1;19)(q23;p13) translocation, which results in the fusion of the E2A gene with the PBX1 gene, forming the E2A-PBX1 fusion protein. This cell line is frequently used in research to study the molecular mechanisms of B-ALL, particularly focusing on the role of the E2A-PBX1 fusion in leukemogenesis. The cell line is also utilized in drug sensitivity studies and gene expression profiling to identify potential therapeutic targets. MHH-CALL-4 is part of the Cancer Cell Line Encyclopedia (CCLE) and is available from the German Collection of Microorganisms and Cell Cultures (DSMZ).

Research Applications

Leukemia researchMolecular mechanisms of B-ALLDrug sensitivity studiesGene expression profiling

Key Characteristics

t(1;19)(q23;p13) translocationE2A-PBX1 fusion proteinB-cell precursor origin

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1410
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	10
Age Category	Pediatric
Sex	Male
Race	caucasian
Subtype Features	CRLF2 Ph-like

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1 Like
OncoTree Code	BLLBCRABL1L

DepMap Information

Source Type	DSMZ
Source ID	ACH-000156_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Leu23Arg (c.68T>G)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

9,10

D16S539

D18S51

13,15

D19S433

15,17

D21S11

29,31.2

D2S1338

D3S1358

D5S818

D7S820

9,11

D8S1179

12,14

FGA

21,23

Penta D

9,13

Penta E

7,12

TH01

7,9.3

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI