MHH-ES-1Homo sapiens (Human)Cancer cell line

Also known as: MHHES1, MHH-ES1

🤖 AI SummaryBased on 9 publications

Quick Overview

Ewing sarcoma cell line with STAG2 and TP53 mutations.

Detailed Summary

MHH-ES-1 is a human Ewing sarcoma cell line established from the ascites of a 12-year-old Turkish boy with peritoneal metastasis. It exhibits STAG2 and TP53 mutations, which are associated with aggressive tumor behavior. The cell line shows a near-diploid karyotype with chromosomal abnormalities including t(11;22) and other structural variations. It is used in research to study the genetic and molecular mechanisms of Ewing sarcoma, particularly focusing on the role of STAG2 and TP53 mutations in tumor progression and therapeutic response.

Research Applications

Genomic analysis of Ewing sarcomaStudy of STAG2 and TP53 mutationsInvestigation of chromosomal abnormalitiesDrug sensitivity profiling

Key Characteristics

STAG2 mutationTP53 mutationNear-diploid karyotypeChromosomal translocations (t(11;22))

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1411
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	12
Age Category	Pediatric
Sex	Male
Race	caucasian
Subtype Features	EWS-FLI

Disease Information

Disease	Ewing sarcoma
Lineage	Bone
Subtype	Ewing Sarcoma
OncoTree Code	ES

DepMap Information

Source Type	DSMZ
Source ID	ACH-000391_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ser215del (c.643_645delAGT)	Unspecified	-	PubMed=25223734
MutationSimple	STAG2	p.Gln735fs	Unspecified	-	PubMed=25223734
Gene fusion	EWSR1	EWSR1-FLI1, EWS-FLI1	-	Type 1 fusion	PubMed=15150091

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

14,16

D19S433

13,15

D21S11

28,32.2

D2S1338

19,25

D3S1358

15,16

D5S818

D7S820

9,11

D8S1179

11,13

FGA

Penta D

11,12

Penta E

11,15

TH01

8,9

TPOX

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.

Zhang J.-H., Delattre O.

Cancer Discov. 4:1342-1353(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.

Borsu L., Barr F.G., Ladanyi M.

Clin. Cancer Res. 18:748-757(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Systematic multi-omics profiling of Ewing sarcoma cell lines.";

Orth M.F.

Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.

DOI

MHH-ES-1, a new Ewing sarcoma cell line.";

Pietsch T., Goettert E., Feickert H.-J., Riehm H., Blin N., Kovacs G.

Cancer Genet. Cytogenet. 38:167-167(1989).

DOI