MHH-NB-11Homo sapiens (Human)Cancer cell line

Also known as: MHHNB11, MHH-NB11

🤖 AI SummaryBased on 6 publications

Quick Overview

MHH-NB-11 is a human neuroblastoma cell line used in cancer research.

Detailed Summary

MHH-NB-11 is a human neuroblastoma cell line derived from a tumor, commonly used in cancer research to study the biology and treatment of neuroblastoma. This cell line is part of a collection of cell lines used for understanding the genetic and molecular characteristics of neuroblastoma. It is utilized in studies involving drug sensitivity, gene expression, and tumor biology. The cell line is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genomic and transcriptomic features, contributing to the understanding of cancer mechanisms and potential therapeutic targets.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1412
Species	Homo sapiens (Human)
Tissue Source	Adrenal gland[UBERON:UBERON_0002369]

Donor Information

Age	4
Age Category	Pediatric
Sex	Male
Race	caucasian
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000078_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

9,13

D18S51

16,17

D19S433

13,17

D21S11

30,31.2

D2S1338

D3S1358

15,17

D5S818

D7S820

8,9

D8S1179

13,14

FGA

20,21

Penta D

11,12

Penta E

5,12

TH01

7,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Characterization of a continuous cell line (MHH-NB-11) derived from advanced neuroblastoma.

Kovacs G.

Anticancer Res. 8:1329-1333(1988).

PubMed

Tumor cell lines of the peripheral nervous system.";

Israel M.A., Thiele C.J.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).

DOI