MJHomo sapiens (Human)Cancer cell line

Also known as: G11

🤖 AI SummaryBased on 7 publications

MJ Cell Line

Quick Overview

Human T cell line with potential for cancer research and drug sensitivity studies.

Detailed Summary

The MJ cell line is a human T cell line derived from a patient with adult T-cell leukemia/lymphoma (ATL). It is characterized by its ability to proliferate in severe combined immunodeficient (SCID) mice, indicating its tumorigenic potential. This cell line has been used in studies examining the role of the human T-cell leukemia virus type I (HTLV-I) in leukemogenesis and the mechanisms of tumor cell growth. Research has shown that the MJ cell line can be engrafted in SCID mice, leading to the development of lymphoma-like tumors. Additionally, the MJ cell line has been utilized to study the effects of viral gene expression and the role of the tax gene in cellular transformation. The cell line's properties make it a valuable tool for investigating the molecular mechanisms underlying ATL and other T-cell malignancies.

Research Applications

Cancer researchDrug sensitivity studiesViral oncogenesisTumor cell growth mechanisms

Key Characteristics

Tumorigenic in SCID miceHTLV-I infectedExpresses viral genesUsed in studies of ATL

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1414
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	50
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Primary cutaneous T-cell lymphoma
Lineage	Lymphoid
Subtype	Mature T and NK Neoplasms
OncoTree Code	MTNN

DepMap Information

Source Type	ATCC
Source ID	ACH-000077_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

12,14

D16S539

11,12

D18S51

16,17

D19S433

12,13

D21S11

28,31.2

D2S1338

D3S1358

15,18

D5S818

11,13

D7S820

8,11

D8S1179

12,15

FGA

23,25

Penta D

11,13

Penta E

7,12

TH01

6,7

TPOX

8,11

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.

Hattori T., Yamabe H., Okuma M., Uchiyama T.

Blood 86:2350-2357(1995).

DOI PubMed

Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.

Gallo R.C., Broder S.

J. Exp. Med. 158:994-999(1983).

DOI PubMed PMC