MKN7Homo sapiens (Human)Cancer cell line

Also known as: MKN 7, MKN-7

🤖 AI SummaryBased on 14 publications

Quick Overview

Human gastric cancer cell line with known genetic alterations and drug sensitivity profiles.

Detailed Summary

MKN7 is a human gastric cancer cell line derived from a stomach tumor. It is widely used in cancer research for studying genetic alterations, drug sensitivity, and molecular mechanisms of tumor progression. The cell line has been characterized in multiple studies for its response to chemotherapeutic agents and has been part of panels for identifying predictive biomarkers for cancer treatment. MKN7 is notable for its role in research on the ZAK isoform and its potential as a target for cancer therapies. It has also been used in studies involving the identification of gene mutations and their impact on cancer cell behavior.

Research Applications

Genetic AlterationsDrug SensitivityMolecular Mechanisms of Tumor ProgressionBiomarker Identification

Key Characteristics

Known genetic alterationsDrug sensitivity profilesZAK isoform involvementMutation analysis
Generated on 6/17/2025

Basic Information

Database IDCVCL_1417
SpeciesHomo sapiens (Human)
Tissue SourceLymph node[UBERON:UBERON_0000029]

Donor Information

Age39
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseGastric tubular adenocarcinoma
LineageEsophagus/Stomach
SubtypeTubular Stomach Adenocarcinoma
OncoTree CodeTSTAD

DepMap Information

Source TypeRIKEN
Source IDACH-000678_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Pro278Ser (c.832C>T)Unspecified-PubMed=24662767, PubMed=21602893

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,13
D13S317
8,12
D16S539
9,10
D18S51
13,18
D21S11
29,32.2
D3S1358
17
D5S818
9,13
D7S820
9
D8S1179
15
FGA
23
Penta D
10,11
Penta E
18
TH01
7,9
TPOX
9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.

Sato K., Iwaya T., Koeda K., Wakabayashi G.

PLoS ONE 9:E90155-E90155(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.

Kong D.-X., Yamori T.

Bioorg. Med. Chem. 20:1947-1951(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

Tomoda H., Yamori T., Tsuruo T.

J. Natl. Cancer Inst. 97:765-777(2005).

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.

Yamori T.

Mol. Cancer Ther. 4:399-412(2005).

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

Molecular characteristics of eight gastric cancer cell lines established in Japan.

Yokozaki H.

Pathol. Int. 50:767-777(2000).

Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.

Naito S., Inoue S., Kinjo M., Tanaka K.

Gann 74:240-247(1983).

Comparison of seven cell lines derived from human gastric carcinomas.

Motoyama T., Hojo H., Watanabe H.

Acta Pathol. Jpn. 36:65-83(1986).

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

Nakatani K., Nakano H., Sugimura T., Terada M.

Cancer Res. 51:5800-5805(1991).

Gastric tumor cell lines.";

Sekiguchi M., Suzuki T.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).

Web Resources