MOLT-16Homo sapiens (Human)Cancer cell line

Also known as: Molt16, MOLT16, MOLT 16, Molt-16

🤖 AI SummaryBased on 12 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line with known TCR gene rearrangements.

Detailed Summary

MOLT-16 is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line derived from a patient with T-cell lineage. It is characterized by specific T-cell receptor (TCR) gene rearrangements, making it a valuable model for studying T-cell malignancies. The cell line exhibits clonal TCR gene rearrangements, which are critical for molecular diagnostics and research into T-cell receptor biology. MOLT-16 is widely used in studies related to T-cell leukemia, including investigations into clonality, genetic alterations, and therapeutic targets. Its well-defined TCR profiles make it a key resource for understanding the molecular mechanisms underlying T-cell malignancies and for developing targeted therapies.

Research Applications

T-cell receptor (TCR) gene rearrangement studiesMolecular diagnostics of T-cell malignanciesClonality analysis in T-cell leukemiaTherapeutic target identification for T-cell malignancies

Key Characteristics

Clonal TCR gene rearrangementsWell-defined TCR profilesUsed in studies of T-cell receptor biology

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1424
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	5
Age Category	Pediatric
Sex	Female
Subtype Features	TAL1

Disease Information

Disease	Precursor T-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	T-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	TLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000918_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	WT1	p.Arg427Trp (c.1279C>T)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	TP53	p.Arg158His (c.473G>A)	Homozygous	-	Unknown, Unknown
MutationSimple	PIK3CA	p.Arg693His (c.2078G>A)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	APC	p.Arg1589His (c.4766G>A)	Heterozygous	-	Unknown, PubMed=22675565
Gene fusion	MYC	TRA@-MYC	-	-	PubMed=15843827, PubMed=9408752

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11,12

D13S317

D16S539

9,10

D18S51

14,15,20

D19S433

10,13

D21S11

32.2,33.2

D2S1338

19,21

D3S1358

14,17

D5S818

11,12

D7S820

D8S1179

FGA

23,24

Penta D

6,10

Penta E

TH01

9,9.3

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOI PubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOI PubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOI PubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOI PubMed

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

DOI PubMed

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Hirai H.

Jpn. J. Cancer Res. 89:33-39(1998).

DOI PubMed PMC

Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16.

Shima-Rich E.A., Harden A.M., McKeithan T.W., Rowley J.D., Diaz M.O.

Genes Chromosomes Cancer 20:363-371(1997).

DOI PubMed

Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.

Drexler H.G., Minowada J.

Hematol. Oncol. 7:115-125(1989).

DOI PubMed

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.

Cheng J., Haas M.

Mol. Cell. Biol. 10:5502-5509(1990).

DOI PubMed PMC

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI