Mono-Mac-1Homo sapiens (Human)Cancer cell line

Also known as: MM1, MONOMAC1, MonoMac1, MONOMAC-1, Monomac-1, Mono Mac 1, MONO-MAC-1

🤖 AI SummaryBased on 7 publications

Quick Overview

Human monocytic cell line for studying immune responses and cancer.

Detailed Summary

Mono-Mac-1 is a human monocytic cell line derived from a patient with acute monoblastic leukemia. It exhibits characteristics of mature monocytes, including phagocytic activity and expression of surface markers like CD14. The cell line is used in research to study monocytic functions, immune responses, and cancer-related processes. It can be differentiated into macrophage-like cells, making it a valuable model for understanding monocyte-macrophage lineage differentiation and their roles in disease.

Research Applications

Immunology researchCancer biologyMonocytic differentiation studiesViral infection modeling

Key Characteristics

Expresses CD14 and CD11bPhagocytic activityDifferentiates into macrophage-like cellsSupports HIV-1 infection

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1425
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	64
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute monoblastic/monocytic leukemia
Lineage	Myeloid
Subtype	Acute Monoblastic/Monocytic Leukemia
OncoTree Code	AMOL

DepMap Information

Source Type	DSMZ
Source ID	ACH-001129_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

11,12

D16S539

D18S51

13,14

D19S433

13,14

D21S11

30,31.2

D2S1338

19,23

D3S1358

14,18

D5S818

11,12

D7S820

10,11

D8S1179

FGA

20,22

Penta D

Penta E

10,11

TH01

8,9.3

TPOX

8,10

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Analysis of p53 status in human cell lines using a functional assay in yeast: detection of new non-sense p53 mutation in codon 124.

Smardova J., Pavlova S., Svitakova M., Grochova D., Ravcukova B.

Oncol. Rep. 14:901-907(2005).

DOI PubMed

Mono Mac 1: a new in vitro model system to study HIV-1 infection in human cells of the mononuclear phagocyte series.

Genois N., Robichaud G.A., Tremblay M.J.

J. Leukoc. Biol. 68:854-864(2000).

DOI PubMed

A model system in haematology and immunology: the human monocytic cell line MONO-MAC-1.

Steube K.G., Teepe D., Meyer C., Zaborski M., Drexler H.G.

Leuk. Res. 21:327-335(1997).

DOI PubMed

Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes.

Riethmuller G.

Int. J. Cancer 41:456-461(1988).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI