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Mono-Mac-6Homo sapiens (Human)Cancer cell line

Also known as: MM6, MONOMAC6, MonoMac6, MonoMac 6, Mono Mac6, Mono Mac 6, MONO-MAC 6, Mono-mac-6, MONO-MAC-6

🤖 AI SummaryBased on 12 publications

Mono-Mac 6

Quick Overview

Human monocytic cell line with characteristics of mature monocytes, used in cancer and immunology research.

Detailed Summary

Mono-Mac 6 is a human monocytic cell line derived from a patient with mononucleosis. It exhibits features of mature monocytes, including CD14 antigen expression, phagocytic ability, and cytokine production. This cell line is widely used as an in vitro model for studying monocyte functions and their role in immune responses. Research on Mono-Mac 6 has contributed to understanding the molecular mechanisms of monocyte activation, cytokine production, and interactions with pathogens. It is also utilized in studies related to leukemia and lymphoma, particularly in investigating the genetic and molecular alterations associated with these malignancies. The cell line's ability to produce cytokines like IL-1, IL-6, and TNF-α makes it valuable for immunological research and drug development.

Research Applications

Cancer researchImmunologyCytokine production studiesLeukemia and lymphoma research

Key Characteristics

CD14 antigen expressionPhagocytic abilityCytokine production (IL-1, IL-6, TNF-α)Mature monocyte-like features

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1426
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	64
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute monoblastic/monocytic leukemia
Lineage	Myeloid
Subtype	Acute Monoblastic/Monocytic Leukemia
OncoTree Code	AMOL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000006_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
Gene fusion	ATP8A2	RUNX1-ATP8A2	-	-	PubMed=31160637
Gene fusion	KMT2A	KMT2A-MLLT3, MLL-MLLT3, MLL-AF9	-	-	PubMed=31701557

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

11,12

D16S539

12

D18S51

13,14

D19S433

13,14

D21S11

30,31.2

D2S1338

19,23

D3S1358

14,18

D5S818

11,12

D7S820

10,11

D8S1179

10,12

FGA

20,22

Penta D

9,11

Penta E

10,11

TH01

8,9.3

TPOX

8,10

vWA

17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Drexler H.G., Quentmeier H., MacLeod R.A.F.

Leukemia 18:227-232(2004).

Cytokine production of the human monocytic cell line Mono Mac 6 in comparison to mature monocytes in peripheral blood mononuclear cells.

Neustock P., Brand J.M., Kruse A., Kirchner H.

Immunobiology 188:293-302(1993).

Molecular analysis of the Mono Mac 6 cell line: detection of an MLL-AF9 fusion transcript.

Super H.J.G., Martinez-Climent J.A., Rowley J.D.

Blood 85:855-856(1995).

Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes.

Riethmuller G.

Int. J. Cancer 41:456-461(1988).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

Web Resources

cells-talk.com web.archive.org thermofisher.com