MUTZ-3Homo sapiens (Human)Cancer cell line

Also known as: Menschliche Und Tierische Zellkulture-3, Mutz3, MUTZ3, Mutz-3

🤖 AI SummaryBased on 8 publications

Quick Overview

Human myeloid leukemia cell line for dendritic cell research.

Detailed Summary

MUTZ-3 is a human myeloid leukemia cell line derived from the DSMZ collection, widely used as a model for dendritic cell (DC) research. It can differentiate into immature and mature DC-like cells, expressing markers such as CD1a, CD80, and CD86. MUTZ-3 is utilized in studies on immune regulation, allergy, and cancer immunotherapy due to its ability to present antigens and activate T-cells. The cell line is also studied for its role in understanding JAK2 mutations and its implications in myeloproliferative disorders. Research includes its application in drug development and functional studies of DCs.

Research Applications

Dendritic cell differentiation and functionAllergy and immune response studiesCancer immunotherapy researchJAK2 mutation analysisDrug development

Key Characteristics

Expresses DC markers like CD1a, CD80, CD86Capable of antigen presentationDifferentiates into immature and mature DC-like cellsUsed in studies of myeloproliferative disorders

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1433
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	29
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute myeloid leukemia with inv3(q21;q26.2) or t(3;3)(q21;q26.2)
Lineage	Myeloid
Subtype	AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
OncoTree Code	AMLGATA2MECOM

DepMap Information

Source Type	DSMZ
Source ID	ACH-000084_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly10_Ala11insGly (c.31_32insGAG)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

12,13

D13S317

8,12

D16S539

D18S51

14,17

D19S433

D21S11

D2S1338

21,23

D3S1358

14,16

D5S818

12,13

D7S820

10,12

D8S1179

12,14

FGA

20,22

Penta D

9,10

Penta E

7,19

TH01

6,9.3

TPOX

8,11

vWA

14,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Sampling from the proteome to the human leukocyte antigen-DR (HLA-DR) ligandome proceeds via high specificity.

van Els C.A.C.M.

Mol. Cell. Proteomics 15:1412-1423(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A human cell line model for interferon-alpha driven dendritic cell differentiation.

van de Loosdrecht A.A.

PLoS ONE 10:E0135219-E0135219(2015).

DOI PubMed PMC

CD34 human hematopoietic progenitor cell line, MUTZ-3, differentiates into functional osteoclasts.

Bottazzo G.F., Berardi A.C.

Exp. Hematol. 35:967-977(2007).

DOI PubMed

Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells.

Larsson K., Lindstedt M., Borrebaeck C.A.K.

Immunology 117:156-166(2006).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.

Pinedo H.M., Scheper R.J.

Blood 100:701-703(2002).

DOI PubMed

Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.

Drexler H.G., Zaborski M., Quentmeier H.

Leukemia 11:541-551(1997).

DOI PubMed

Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.

Drexler H.G.

Leukemia 10:1025-1040(1996).

PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI