MoHomo sapiens (Human)Cancer cell line
Also known as: MOT, MoT, Mo T, Mo-T, MO
🤖 AI SummaryBased on 5 publications
Mo Cell Line
Quick Overview
Human T-cell line with applications in leukemia and lymphoma research.
Detailed Summary
The Mo cell line is a human T-cell line derived from a patient with a T-cell variant of hairy-cell leukemia. It has been extensively studied for its role in understanding T-cell malignancies and has been used in research related to human T-cell leukemia virus (HTLV-II). The Mo cell line is known for its ability to produce erythroid-potentiating activity (EPA), which enhances the growth of human erythroid progenitors in vitro. Additionally, the Mo cell line has been utilized in studies examining the interactions between T cells and other hematopoietic cells, as well as in the investigation of cell signaling pathways and immune responses. The cell line has also been used to study the effects of serum-free culture conditions on cell growth and differentiation. The Mo cell line is a valuable tool for researchers studying T-cell biology, viral infections, and hematopoietic disorders.
Research Applications
Leukemia and lymphoma researchHuman T-cell leukemia virus (HTLV-II) studiesErythroid-potentiating activity (EPA) researchT-cell biology and immune response studiesSerum-free culture conditions and cell differentiation
Key Characteristics
Derived from a T-cell variant of hairy-cell leukemiaProduces erythroid-potentiating activity (EPA)Used in HTLV-II researchCapable of growth in serum-free mediumExpresses T-cell markers
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1439 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Spleen[UBERON:UBERON_0002106] |
Donor Information
| Age | 33 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Classic hairy cell leukemia |
|---|---|
| Lineage | Lymphoid |
| Subtype | Hairy Cell Leukemia |
| OncoTree Code | HCL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001571_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
9,13
D16S539
11
D18S51
11,16
D19S433
14,15
D21S11
31,32.2
D2S1338
19,23
D3S1358
16,17
D5S818
11,12
D7S820
9,12
D8S1179
11,13
FGA
21,22
Penta D
12,13
Penta E
7,17
TH01
9.3
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Production of erythroid-potentiating activity by a human T-lymphoblast cell line.
Golde D.W., Bersch N., Quan S.G., Lusis A.J.
Proc. Natl. Acad. Sci. U.S.A. 77:593-596(1980).
Erythroid-potentiating activity: characterization and target cells.";
Gauwerky C.E., Lusis A.J., Golde D.W.
Exp. Hematol. 8 Suppl. 8:117-127(1980).
A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia.
Golde D.W., Gallo R.C.
Science 218:571-573(1982).
Growth of human malignant lymphoid cell lines in serum-free medium.";
Uittenbogaart C.H., Cantor Y., Fahey J.L.
In Vitro 19:67-72(1983).
Anecdotal Information
- John Moore, the patient from which this cell line is derived, sued David Golde and the University of California over the patent that they deposited on the Mo cell line. Although his claims of ownership were rejected, his physician was deemed to have breached his fiduciary duty by not informing Moore of the economic and financial interests arising from the derivation of the cell line