NCI-H1341Homo sapiens (Human)Cancer cell line

Also known as: NCIH1341, H-1341, H1341

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origins, used in cancer research.

Detailed Summary

The NCI-H1341 cell line is a human cancer cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in various studies related to cancer genomics and drug sensitivity. The cell line has been analyzed for genetic diversity and ancestry, highlighting its potential in understanding cancer disparities. Research has shown that it retains heterozygosity at certain loci on chromosome 3p, which may have implications for its use in studying cancer biology and therapeutic responses.

Research Applications

Cancer genomicsDrug sensitivity studiesGenetic diversity and ancestry analysis

Key Characteristics

Retains heterozygosity at 3p lociPart of the CCLE databaseUsed in studies on cancer disparities

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1463
Species	Homo sapiens (Human)
Tissue Source	Uterus, cervix[UBERON:UBERON_0000002]

Donor Information

Age	26
Age Category	Adult
Sex	Female

Disease Information

Disease	High-grade neuroendocrine carcinoma of the cervix uteri
Lineage	Lung
Subtype	SMARCA4-deficient undifferentiated tumor

DepMap Information

Source Type	ATCC
Source ID	ACH-000129_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

12,13

D16S539

D18S51

13,14

D19S433

14,15

D21S11

28,30

D2S1338

D3S1358

14,16

D5S818

D7S820

D8S1179

12,15

FGA

21,24

Penta D

9,13

Penta E

7,15

TH01

6,9.3

TPOX

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies.

Burr M.L., Sutherland K.D.

Clin. Cancer Res. 30:1846-1858(2024).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Lung cancer cell lines as tools for biomedical discovery and research.

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

J. Natl. Cancer Inst. 102:1310-1321(2010).

DOI PubMed PMC

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies.

Simmons A.M., Russell E., Nam M.H., Gazdar A.F.

J. Natl. Cancer Inst. 81:1223-1228(1989).

DOI PubMed

Neuromedin B is present in lung cancer cell lines.";

Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.

Cancer Res. 52:2732s-2736s(1992).

PubMed