NCI-H1385Homo sapiens (Human)Cancer cell line

Also known as: NCIH1385, H-1385, H1385

🤖 AI SummaryBased on 8 publications

Quick Overview

Human squamous cell lung cancer cell line with known IGF expression and RB status.

Detailed Summary

NCI-H1385 is a human squamous cell lung cancer cell line derived from a patient with lung cancer. It is characterized by the expression of insulin-like growth factor (IGF) genes and has been studied for its role in cancer progression. The cell line has been analyzed for its RB (retinoblastoma) protein status, which is a key tumor suppressor gene. Research on NCI-H1385 has contributed to understanding the molecular mechanisms of lung cancer, including the identification of genetic alterations and their implications for therapeutic strategies. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to drug sensitivity and resistance.

Research Applications

IGF expression analysisRB protein status investigationDrug sensitivity profilingGenomic and transcriptomic studies

Key Characteristics

IGF-I and IGF-II expressionRB protein expression statusPart of CCLEUsed in cancer research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1466
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	49
Age Category	Adult
Sex	Female

Disease Information

Disease	Lung squamous cell carcinoma
Lineage	Lung
Subtype	Lung Squamous Cell Carcinoma
OncoTree Code	LUSC

DepMap Information

Source Type	ATCC
Source ID	ACH-000737_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Cys (c.34G>T)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

9,11

D18S51

14,17

D19S433

11.2,13

D21S11

D2S1338

20,23

D3S1358

14,18

D5S818

D7S820

8,10

D8S1179

14,16

FGA

Penta D

Penta E

7,12

TH01

TPOX

8,9

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Insulin-like growth factor expression in human cancer cell lines.";

Grimley C., Battey J., Mulshine J.L., Cuttitta F.

J. Biol. Chem. 271:11477-11483(1996).

DOI PubMed

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).

PubMed

Web Resources

tcpaportal.org