NCI-H1417Homo sapiens (Human)Cancer cell line

Also known as: NCIH1417, H-1417, H1417

🤖 AI SummaryBased on 7 publications

Quick Overview

Human small cell lung cancer cell line with known genetic alterations.

Detailed Summary

The NCI-H1417 cell line is a human small cell lung cancer (SCLC) cell line derived from a patient with lung cancer. It is widely used in cancer research to study the molecular mechanisms of SCLC, including the role of specific genes and pathways in tumor progression. Research has identified several genetic alterations in this cell line, including amplifications and deletions that may contribute to its malignant phenotype. These alterations include the MYC family, which is known to play a significant role in the development and progression of various cancers. The cell line is also used to evaluate the efficacy of targeted therapies, such as PARP inhibitors and Bcl-2 antagonists, which have shown promise in preclinical studies. Additionally, the NCI-H1417 cell line has been utilized in studies examining the impact of genetic diversity on cancer outcomes and the development of precision medicine approaches.

Research Applications

Small cell lung cancer researchGenetic alteration analysisDrug efficacy testingPrecision medicine studies

Key Characteristics

MYC family amplificationPARP1 expressionBcl-2 inhibitor sensitivityGenetic diversity studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1469
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	61
Age Category	Adult
Sex	Female

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-001591_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg175Leu (c.524G>T)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

8,11

D16S539

12,13

D18S51

17,18

D19S433

13.2,16

D21S11

28,29

D2S1338

20,24

D3S1358

D5S818

D7S820

8,10

D8S1179

12,14

FGA

21,22

Penta D

9,13

Penta E

9,10

TH01

8,9.3

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Sauter G., Lesniewski R., Semizarov D.

Mol. Cancer Res. 5:331-339(2007).

DOI PubMed

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed