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NCI-H1435Homo sapiens (Human)Cancer cell line

Also known as: NCIH1435, H-1435, H1435

🤖 AI SummaryBased on 8 publications

Quick Overview

Human lung cancer cell line with known RB and RBL2 status.

Detailed Summary

The NCI-H1435 cell line is a human lung cancer cell line derived from a non-small cell lung cancer (NSCLC) patient. It is characterized by specific genetic alterations, including mutations in the RB and RBL2 genes. The RB gene, a key tumor suppressor, is often inactivated in various cancers, and NCI-H1435 exhibits mutations that may contribute to its tumorigenic potential. Additionally, the RBL2 gene, part of the RB-related family, shows specific alterations in this cell line. These genetic features make NCI-H1435 a valuable model for studying the molecular mechanisms of lung cancer progression and for evaluating therapeutic strategies targeting these pathways. The cell line is also part of larger datasets like the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to drug sensitivity and genomic profiling.

Research Applications

Genomic profilingDrug sensitivity testingMolecular mechanism studies

Key Characteristics

RB gene mutationsRBL2 gene alterationsPart of CCLE dataset

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1470
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	35
Age Category	Adult
Sex	Female

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000852_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys141Trp (c.423C>G)	Unspecified	-	Unknown
MutationSimple	TERT	c.1-124C>A (c.228C>A) (C228A)	Unspecified	In promoter	PubMed=31068700
MutationSimple	APC	p.Arg1158fs*7 (c.3471_3476GAGACC>AAAAA)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

13

D13S317

8,11

D16S539

11

D18S51

17

D19S433

15

D21S11

30

D2S1338

17,25

D3S1358

17

D5S818

11

D7S820

12,14

D8S1179

12,13

FGA

22

Penta D

11,12

Penta E

5,12

TH01

6,7

TPOX

8

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).

Web Resources