NCI-H1436Homo sapiens (Human)Cancer cell line

Also known as: NCIH1436, H-1436, H1436

🤖 AI SummaryBased on 7 publications

Quick Overview

Human lung cancer cell line with known RB mutations and potential for drug sensitivity studies.

Detailed Summary

The NCI-H1436 cell line is a human lung cancer cell line derived from a patient with small cell lung cancer. It is characterized by mutations in the RB gene, which is a key tumor suppressor involved in cell cycle regulation. This cell line has been used in studies examining the role of RB-related genes in lung cancer progression and drug sensitivity. The presence of RB mutations suggests its utility in research focused on understanding the molecular mechanisms of lung cancer and developing targeted therapies. Additionally, NCI-H1436 has been included in large-scale cancer cell line databases, such as the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive genomic and pharmacological profiles for research purposes.

Research Applications

RB gene mutation analysisDrug sensitivity studiesCancer genomics research

Key Characteristics

RB gene mutationsSmall cell lung cancer origin

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1471
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Additional Information	Established from a 75 packs per year smoker (ATCC=CRL-5871)
Age	39
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000830_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.His179Gln (c.537T>G)	Unspecified	-	PubMed=1565469, PubMed=1312696

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

D16S539

D18S51

14,17

D19S433

14,15

D21S11

30.2,32.2

D2S1338

17,21

D3S1358

D5S818

11,13

D7S820

9,11

D8S1179

8,13

FGA

19,21

Penta D

9,13

Penta E

TH01

7,9.3

TPOX

9,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.

Linnoila R.I.

Oncogene 7:743-749(1992).

PubMed

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.

Gazdar A.F., Minna J.D.

Oncogene 7:339-346(1992).

PubMed