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NCI-H1573Homo sapiens (Human)Cancer cell line

Also known as: NCIH1573, H-1573, H1573

🤖 AI SummaryBased on 9 publications

Quick Overview

Human lung cancer cell line with known RB gene status and potential for drug sensitivity studies.

Detailed Summary

The NCI-H1573 cell line is a human lung cancer cell line derived from a non-small cell lung cancer (NSCLC) patient. It is characterized by specific genetic alterations, including mutations in the RB gene, which is a key tumor suppressor involved in cell cycle regulation. This cell line has been used in studies examining the role of RB-related genes in lung cancer progression and has been part of large-scale genomic and transcriptomic analyses to identify potential therapeutic targets. The cell line is also included in comprehensive cancer cell line databases, providing valuable resources for research on drug sensitivity and resistance mechanisms.

Research Applications

Genomic and transcriptomic analysisDrug sensitivity and resistance studiesRB gene mutation analysis

Key Characteristics

RB gene mutationsNon-small cell lung cancer originInclusion in large cancer cell line databases

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1478
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	35
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000916_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Leu (c.743G>T)	Unspecified	-	PubMed=18487078
MutationSimple	PTPN11	p.Arg351Ter (c.1051C>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	NRAS	p.Gln61Lys (c.181C>A)	Unspecified	Acquired during resistance selection process	PubMed=26214590
MutationSimple	KRAS	p.Gly12Ala (c.35G>C)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

11,13

D16S539

12

D18S51

14

D19S433

13

D21S11

29

D2S1338

17,23

D3S1358

17

D5S818

11,13

D7S820

9,11

D8S1179

13,14

FGA

20,22

Penta D

11,13

Penta E

12,15

TH01

6

TPOX

8,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).

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