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NCI-H1581Homo sapiens (Human)Cancer cell line

Also known as: NCIH1581, H-1581, H1581

🤖 AI SummaryBased on 9 publications

Quick Overview

Human lung cancer cell line with RB pathway alterations and potential for drug sensitivity studies.

Detailed Summary

The NCI-H1581 cell line is a human lung cancer cell line derived from a non-small cell lung carcinoma. It is characterized by specific genetic alterations in the RB pathway, including mutations or inactivation of the RB gene, which is a critical tumor suppressor involved in cell cycle regulation. These alterations may contribute to the uncontrolled proliferation of cancer cells. The cell line has been used in studies investigating the role of the RB family members, such as RBL1 and RBL2, in cancer progression and therapeutic responses. Additionally, NCI-H1581 has been part of large-scale genomic and transcriptomic analyses, contributing to the understanding of cancer heterogeneity and drug response profiles. Its utility in preclinical research is highlighted by its inclusion in comprehensive cell line databases and its potential for identifying novel therapeutic targets.

Research Applications

RB pathway analysisDrug sensitivity profilingGenomic and transcriptomic studiesCancer heterogeneity research

Key Characteristics

RB gene inactivationPotential for studying RB family membersInclusion in large-scale cancer cell line databases

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1479
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	44
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung large cell carcinoma
Lineage	Lung
Subtype	Large Cell Lung Carcinoma
OncoTree Code	LCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000015_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gln144Ter (c.430C>T)	Heterozygous	-	PubMed=29970484, PubMed=11799138, PubMed=8782485, PubMed=8725545
MutationSimple	APC	p.Ala1107fs*12 (c.3317_3318insG)	Homozygous	-	Unknown, Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

11

D16S539

9

D18S51

15

D19S433

14

D21S11

29,31

D2S1338

24,25

D3S1358

14

D5S818

12

D7S820

9,11

D8S1179

10,14

FGA

22

Penta D

13

Penta E

12,17

TH01

6,7

TPOX

8,9

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

Neuromedin B is present in lung cancer cell lines.";

Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.

Cancer Res. 52:2732s-2736s(1992).

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).

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