NCI-H1688Homo sapiens (Human)Cancer cell line
Also known as: NCIH1688, H-1688, H1688
🤖 AI SummaryBased on 3 publications
Quick Overview
Human lung cancer cell line for research on genetic diversity and ancestry.
Detailed Summary
The NCI-H1688 cell line is a human lung cancer cell line derived from a patient with small cell lung cancer. It is part of a comprehensive collection of cancer cell lines used to study genetic diversity and ancestry in cancer research. This cell line is utilized to investigate the impact of genetic ancestry on cancer disparities and to develop more inclusive models for precision medicine. Researchers use NCI-H1688 to explore the molecular mechanisms underlying cancer progression and to test therapeutic strategies. The cell line's genetic profile provides insights into the heterogeneity of cancer and contributes to the understanding of how ancestry influences cancer biology and treatment outcomes.
Research Applications
Genetic diversity and ancestry studiesCancer disparities researchPrecision medicine development
Key Characteristics
Human lung cancer cell lineUsed in studies of genetic ancestryContributes to understanding of cancer disparities
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1487 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 50 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-002170_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln192Ter (c.574C>T) | Unspecified | - | PubMed=28273451, PubMed=22931248 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
8
D16S539
13
D18S51
14,16
D19S433
13
D21S11
30
D2S1338
18,23
D3S1358
18
D5S818
10
D7S820
12
D8S1179
13
FGA
20,22.2
Penta D
13
Penta E
11,12
TH01
6,8
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.
Tang X.X., Brodeur G.M., Campling B.G., Ikegaki N.
Clin. Cancer Res. 5:455-460(1999).
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
Ihde D.C., Gazdar A.F.
J. Cell. Biochem. Suppl. 24:210-217(1996).