NCI-H1694Homo sapiens (Human)Cancer cell line

Also known as: NCIH1694, H-1694, H1694

🤖 AI SummaryBased on 8 publications

Quick Overview

Human small cell lung cancer cell line with known genetic alterations.

Detailed Summary

The NCI-H1694 cell line is a human-derived small cell lung cancer (SCLC) cell line that has been extensively studied for its genetic and molecular characteristics. It is notable for its role in research on the dysregulation of pathways such as the E2F1 pathway and DNA repair mechanisms, particularly involving PARP1. This cell line has been used in studies to identify potential therapeutic targets, including the evaluation of PARP inhibitors and their efficacy in SCLC. The cell line is also part of large-scale genomic and pharmacological profiling efforts, such as the Cancer Cell Line Encyclopedia (CCLE), which has provided insights into drug sensitivity and resistance patterns. Additionally, NCI-H1694 has been utilized in investigations into the role of specific genes like PARD3 in cell polarity and tumor progression, highlighting its importance in understanding the molecular mechanisms underlying SCLC.

Research Applications

Genomic and pharmacological profilingTherapeutic target identificationDrug sensitivity and resistance studiesMolecular mechanisms of SCLC progression

Key Characteristics

Overexpression of PARP1Dysregulation of E2F1 pathwayRole in DNA repair mechanismsPart of the Cancer Cell Line Encyclopedia (CCLE)

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1489
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	61
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000431_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.783-1G>T	Unspecified	Splice acceptor mutation	PubMed=33802339

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

9,11

D18S51

15,17

D19S433

12,13

D21S11

D2S1338

19,20

D3S1358

D5S818

D7S820

D8S1179

12,13

FGA

Penta D

Penta E

11,12

TH01

6,9

TPOX

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Neuromedin B is present in lung cancer cell lines.";

Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.

Cancer Res. 52:2732s-2736s(1992).

PubMed